Emerging Roles of Fibroblast Growth Factor 10 in Cancer

Natasha S Clayton, Richard P Grose

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Factor 10 (FGF10) has been implicated in multiple cancers, including breast, prostate and pancreatic ductal adenocarcinoma. Here, we examine the mechanisms underlying FGF10-induced tumourigenesis and explore novel approaches to target FGF10 signaling in cancer.

Original languageEnglish
Article number499
Number of pages7
JournalFrontiers in Genetics
Volume9
Early online date24 Oct 2018
DOIs
Publication statusE-pub ahead of print - 24 Oct 2018

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