Emotional symptoms in children: The effect of maternal depression, life events and COMT genotype

Jonathan P Evans, K Xu, Jon E Heron, MA Enoch, Ricardo Araya, Glyn H Lewis, NJ Timpson, Simon J C Davies, David J Nutt, D Goldman

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)

Abstract

Early adversity predicts anxiety and depression but variation in response to adversity is not understood. We investigated whether association between early adversity and emotional symptoms in young children differs according to variation of the COMT gene. The main outcome measure was the emotionality subscale of the Strengths and Difficulties Questionnaire (SDQ) completed by mothers for 8,431 children aged 6–7 years old in the Avon Longitudinal Study of Parents and Children. Adversity measures included exposure to maternal postpartum depressive symptoms and adverse life events for children. DNA from the children was genotyped for five COMT polymorphisms including the COMT Val158Met locus. Maternal depression increased the odds of high emotionality in the children, (OR 1.99, 95% CI 1.73–2.29, P
Translated title of the contributionEmotional symptoms in children: The effect of maternal depression, life events and COMT genotype
Original languageEnglish
Pages (from-to)209 - 218
Number of pages9
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume150b
DOIs
Publication statusPublished - 2009

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