Emotional symptoms in children: The effect of maternal depression, life events and COMT genotype

Jonathan P Evans; K Xu; Jon E Heron; MA Enoch; Ricardo Araya; Glyn H Lewis; NJ Timpson; Simon J C Davies; David J Nutt; D Goldman

doi:10.1002/ajmg.b.30789

Emotional symptoms in children: The effect of maternal depression, life events and COMT genotype

Jonathan P Evans, K Xu, Jon E Heron, MA Enoch, Ricardo Araya, Glyn H Lewis, NJ Timpson, Simon J C Davies, David J Nutt, D Goldman

Research output: Contribution to journal › Article (Academic Journal) › peer-review

19 Citations (Scopus)

Abstract

Early adversity predicts anxiety and depression but variation in response to adversity is not understood. We investigated whether association between early adversity and emotional symptoms in young children differs according to variation of the COMT gene. The main outcome measure was the emotionality subscale of the Strengths and Difficulties Questionnaire (SDQ) completed by mothers for 8,431 children aged 6–7 years old in the Avon Longitudinal Study of Parents and Children. Adversity measures included exposure to maternal postpartum depressive symptoms and adverse life events for children. DNA from the children was genotyped for five COMT polymorphisms including the COMT Val158Met locus. Maternal depression increased the odds of high emotionality in the children, (OR 1.99, 95% CI 1.73–2.29, P

Translated title of the contribution	Emotional symptoms in children: The effect of maternal depression, life events and COMT genotype
Original language	English
Pages (from-to)	209 - 218
Number of pages	9
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	150b
DOIs	https://doi.org/10.1002/ajmg.b.30789
Publication status	Published - 2009

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title = "Emotional symptoms in children: The effect of maternal depression, life events and COMT genotype",

abstract = "Early adversity predicts anxiety and depression but variation in response to adversity is not understood. We investigated whether association between early adversity and emotional symptoms in young children differs according to variation of the COMT gene. The main outcome measure was the emotionality subscale of the Strengths and Difficulties Questionnaire (SDQ) completed by mothers for 8,431 children aged 6–7 years old in the Avon Longitudinal Study of Parents and Children. Adversity measures included exposure to maternal postpartum depressive symptoms and adverse life events for children. DNA from the children was genotyped for five COMT polymorphisms including the COMT Val158Met locus. Maternal depression increased the odds of high emotionality in the children, (OR 1.99, 95% CI 1.73–2.29, P",

author = "Evans, {Jonathan P} and K Xu and Heron, {Jon E} and MA Enoch and Ricardo Araya and Lewis, {Glyn H} and NJ Timpson and Davies, {Simon J C} and Nutt, {David J} and D Goldman",

year = "2009",

doi = "10.1002/ajmg.b.30789",

language = "English",

volume = "150b",

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journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

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TY - JOUR

T1 - Emotional symptoms in children: The effect of maternal depression, life events and COMT genotype

AU - Evans, Jonathan P

AU - Xu, K

AU - Heron, Jon E

AU - Enoch, MA

AU - Araya, Ricardo

AU - Lewis, Glyn H

AU - Timpson, NJ

AU - Davies, Simon J C

AU - Nutt, David J

AU - Goldman, D

PY - 2009

Y1 - 2009

N2 - Early adversity predicts anxiety and depression but variation in response to adversity is not understood. We investigated whether association between early adversity and emotional symptoms in young children differs according to variation of the COMT gene. The main outcome measure was the emotionality subscale of the Strengths and Difficulties Questionnaire (SDQ) completed by mothers for 8,431 children aged 6–7 years old in the Avon Longitudinal Study of Parents and Children. Adversity measures included exposure to maternal postpartum depressive symptoms and adverse life events for children. DNA from the children was genotyped for five COMT polymorphisms including the COMT Val158Met locus. Maternal depression increased the odds of high emotionality in the children, (OR 1.99, 95% CI 1.73–2.29, P

AB - Early adversity predicts anxiety and depression but variation in response to adversity is not understood. We investigated whether association between early adversity and emotional symptoms in young children differs according to variation of the COMT gene. The main outcome measure was the emotionality subscale of the Strengths and Difficulties Questionnaire (SDQ) completed by mothers for 8,431 children aged 6–7 years old in the Avon Longitudinal Study of Parents and Children. Adversity measures included exposure to maternal postpartum depressive symptoms and adverse life events for children. DNA from the children was genotyped for five COMT polymorphisms including the COMT Val158Met locus. Maternal depression increased the odds of high emotionality in the children, (OR 1.99, 95% CI 1.73–2.29, P

U2 - 10.1002/ajmg.b.30789

DO - 10.1002/ajmg.b.30789

M3 - Article (Academic Journal)

C2 - 18535998

VL - 150b

SP - 209

EP - 218

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

ER -

Emotional symptoms in children: The effect of maternal depression, life events and COMT genotype

Abstract

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