Enabling Fast Pseudo-2D NMR Spectral Acquisition for Broadband Homonuclear Decoupling: The EXACT NMR Approach

Ikenna E. Ndukwe, Alexandra Shchukina, Vadim Zorin, Carlos Cobas, Krzysztof Kazimierczuk*, Craig P. Butts

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

10 Citations (Scopus)
274 Downloads (Pure)

Abstract

Pseudo-2D NMR spectroscopy provides a means of acquiring broadband homonuclear decoupled spectra useful for structural characterization of complex molecules. However, data points concatenated in the direct dimension in these experiments are acquired over incremented time periods-leading to long acquisition times with no sensitivity benefits due to the absence of signal averaging between scans. Herein, the concept of EXACT NMR spectroscopy ("burst" non-uniform sampling of data points) is explored in pseudo-2D experiments with results revealing little or no loss in spectral quality or signal intensity despite the acceleration of acquisition-up to 400% in some cases.
Original languageEnglish
Pages (from-to)2081–2087
Number of pages7
JournalChemPhysChem
Volume18
Issue number15
Early online date8 Jun 2017
DOIs
Publication statusPublished - 5 Aug 2017

Keywords

  • EXACT
  • Homonuclear decoupling
  • Non-uniform sampling
  • Pseudo-2D NMR spectroscopy
  • Pure shift

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