Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines

XiaoFeng Ma, Ian Hazelden, Thomas Langer, Rachel Munday, John Bower

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)
57 Downloads (Pure)

Abstract

Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates. The method provides versatile access to challenging N-heterocycles and represents
the broadest scope enantioselective aza-Heck protocol developed so far.
Original languageEnglish
Pages (from-to)3356-3360
Number of pages5
JournalJournal of the American Chemical Society
Volume141
Issue number8
Early online date9 Feb 2019
DOIs
Publication statusPublished - 18 Feb 2019

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