Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines

XiaoFeng Ma; Ian Hazelden; Thomas Langer; Rachel Munday; John Bower

doi:10.1021/jacs.8b12689

Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines

XiaoFeng Ma, Ian Hazelden, Thomas Langer, Rachel Munday, John Bower

Research output: Contribution to journal › Article (Academic Journal)

11 Citations (Scopus)

57 Downloads (Pure)

Abstract

Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates. The method provides versatile access to challenging N-heterocycles and represents
the broadest scope enantioselective aza-Heck protocol developed so far.

Original language	English
Pages (from-to)	3356-3360
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	141
Issue number	8
Early online date	9 Feb 2019
DOIs	https://doi.org/10.1021/jacs.8b12689
Publication status	Published - 18 Feb 2019

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10.1021/jacs.8b12689

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Ma, X., Hazelden, I., Langer, T., Munday, R., & Bower, J. (2019). Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines. Journal of the American Chemical Society, 141(8), 3356-3360. https://doi.org/10.1021/jacs.8b12689

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