Abstract
An asymmetric copper-catalyzed alkylation of quinoline N-oxides with chiral Cu–alkyl species, generated by migratory insertion of a vinylarene into a chiral Cu−H complex, is reported. A variety of quinoline N-oxides and vinylarenes underwent this Cu-catalyzed enantioselective alkylation reaction, affording the corresponding chiral alkylated N-heteroarenes in high yield with high-to-excellent enantioselectivity. This enantioselective protocol represents the first general and practical approach to access a wide range of chiral alkylated quinolines.
Original language | English |
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Pages (from-to) | 15896-15900 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 56 |
Issue number | 50 |
Early online date | 16 Oct 2017 |
DOIs | |
Publication status | Published - 11 Dec 2017 |
Keywords
- alkylation
- asymmetric catalysis
- copper
- quinoline N-oxides
- vinylarenes