Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

James R Smith, Beatrice S L Collins, Matthew J Hesse, Mark A Graham, Eddie L Myers, Varinder K Aggarwal

Research output: Contribution to journalArticle (Academic Journal)peer-review

53 Citations (Scopus)
268 Downloads (Pure)

Abstract

We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp(2)-sp(3) hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.

Original languageEnglish
Pages (from-to)9148-9151
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number27
DOIs
Publication statusPublished - 30 Jun 2017

Structured keywords

  • BCS and TECS CDTs

Keywords

  • Journal Article

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