By exploiting the thermal instability about the Ar-CO axis at high temperature, atropisomeric amides can be dynamically resolved to provide material with up to 96.5% ee in 70-80% overall yield from racemic starting material. The amides are coupled with a diamine resolving agent and equilibrated to single diastereoisomers. Hydrolysis returns enantiomerically enriched amide (see reaction scheme).
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 3 Sep 1999|
- Asymmetric synthesis
- Dynamic resolution