Projects per year
Abstract
A convergent, nine-step (LLS), enantioselective synthesis of α-cyclopiazonic acid and related natural products is reported. The route features a)an enantioselective aziridination of an imine with a chiral sulfur ylide; b)a bioinspired (3+2)-cycloaddition of the aziridine onto an alkene; and c)installation of the acetyltetramic acid by an unprecedented tandem carbonylative lactamization/N-O cleavage of a bromoisoxazole.
Original language | English |
---|---|
Pages (from-to) | 1346–1350 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 57 |
Issue number | 5 |
Early online date | 9 Jan 2018 |
DOIs | |
Publication status | Published - 22 Jan 2018 |
Keywords
- (3+2)-cycloaddition
- Aziridination
- Sulfur ylide
- Total synthesis
- α-cyclopiazonic acid
Fingerprint
Dive into the research topics of 'Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides'. Together they form a unique fingerprint.Projects
- 4 Finished
-
FRESCO: Efficient, Flexible Synthesis of Molecules with Tailored Shapes: from Photoswitchable Helices to anti-Cancer Compounds
Aggarwal, V. K. (Principal Investigator)
1/10/15 → 31/03/21
Project: Research
-
A 13C NMR Coldprobe to Underpin Chemistry Research.
Butts, C. P. (Principal Investigator)
28/02/14 → 29/11/17
Project: Research
-
3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
Profiles
-
Professor Varinder K Aggarwal
- School of Chemistry - Alfred Capper Pass Chair of Chemistry
Person: Academic