Endocytosis of G protein-coupled receptors is regulated by clathrin light chain phosphorylation

Filipe Ferreira, Matthew Foley, Alex Cooke, Margaret Cunningham, Gemma Smith, Robert Woolley, Graeme Henderson, Eamonn Kelly, Stuart Mundell, Elizabeth Smythe

Research output: Contribution to journalArticle (Academic Journal)peer-review

34 Citations (Scopus)

Abstract

Signaling by transmembrane receptors such as G protein-coupled receptors (GPCRs) occurs at the cell surface and throughout the endocytic pathway, and signaling from the cell surface may differ in magnitude and downstream output from intracellular signaling. As a result, the rate at which signaling molecules traverse the endocytic pathway makes a significant contribution to downstream output. Modulation of the core endocytic machinery facilitates differential uptake of individual cargoes. Clathrin-coated pits are a major entry portal where assembled clathrin forms a lattice around invaginating buds that have captured endocytic cargo. Clathrin assembles into triskelia composed of three clathrin heavy chains and associated clathrin light chains (CLCs). Despite the identification of clathrin-coated pits at the cell surface over 30 years ago, the functions of CLCs in endocytosis have been elusive.
Original languageEnglish
Pages (from-to)1361-70
Number of pages10
JournalCurrent Biology
Volume22
Issue number15
DOIs
Publication statusPublished - Aug 2012

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