Endosomal Retrieval of Cargo: Retromer Is Not Alone

Kerrie E. McNally, Peter J. Cullen*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

40 Citations (Scopus)
284 Downloads (Pure)

Abstract

Endosomes are major protein sorting stations in cells. Endosomally localised multi-protein complexes sort integral proteins, including signaling receptors, nutrient transporters, adhesion molecules, and lysosomal hydrolase receptors, for lysosomal degradation or conversely for retrieval and subsequent recycling to various membrane compartments. Correct endosomal sorting of these proteins is essential for maintaining cellular homeostasis, with defects in endosomal sorting implicated in various human pathologies including neurodegenerative disorders. Retromer, an ancient multi-protein complex, is essential for the retrieval and recycling of hundreds of transmembrane proteins. While retromer is a major player in endosomal retrieval and recycling, several studies have recently identified retrieval mechanisms that are independent of retromer. Here, we review endosomal retrieval complexes, with a focus on recently discovered retromer-independent mechanisms.

Original languageEnglish
Pages (from-to)807-822
Number of pages16
JournalTrends in Cell Biology
Volume28
Issue number10
Early online date30 Jul 2018
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • endosomes
  • retromer
  • retriever
  • WASH complex
  • CCC complex
  • sorting nexin (SNX)

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