Endothelia response to childhood infection: The role of mannose-binding lectin (MBL)

M Charkida; AE Donald; Sam D Leary; JP Halcox; MW Turner; M Johson; SP Loukogeorgakis; G Davey Smith; MI Okorie; JE Deanfield; NJ Klein

doi:10.1016/j.atherosclerosis.2009.07.055

Endothelia response to childhood infection: The role of mannose-binding lectin (MBL)

M Charkida, AE Donald, Sam D Leary, JP Halcox, MW Turner, M Johson, SP Loukogeorgakis, G Davey Smith, MI Okorie, JE Deanfield, NJ Klein

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

OBJECTIVE: To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood. METHODS: We studied 2176 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. Endothelial function was assessed by flow mediated dilatation (FMD). Exon 1 and promoter polymorphisms in the MBL gene were determined by heteroduplexing procedures. Children were classified as AA (wild type) AO (heterozygotes) and OO (homozygotes). RESULTS: During the vascular assessment, 544 children presented with current or recent (

Translated title of the contribution	Endothelia response to childhood infection: The role of mannose-binding lectin (MBL)
Original language	English
Pages (from-to)	217 - 221
Number of pages	4
Journal	European Heart Journal
Volume	31
DOIs	https://doi.org/10.1016/j.atherosclerosis.2009.07.055
Publication status	Published - Jan 2010

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EXTENSION OF RD1321 VIA IOP.
Golding, J. (Principal Investigator)
1/02/01 → 1/02/06
Project: Research

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title = "Endothelia response to childhood infection: The role of mannose-binding lectin (MBL)",

abstract = "OBJECTIVE: To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood. METHODS: We studied 2176 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. Endothelial function was assessed by flow mediated dilatation (FMD). Exon 1 and promoter polymorphisms in the MBL gene were determined by heteroduplexing procedures. Children were classified as AA (wild type) AO (heterozygotes) and OO (homozygotes). RESULTS: During the vascular assessment, 544 children presented with current or recent (",

author = "M Charkida and AE Donald and Leary, {Sam D} and JP Halcox and MW Turner and M Johson and SP Loukogeorgakis and {Davey Smith}, G and MI Okorie and JE Deanfield and NJ Klein",

year = "2010",

month = jan,

doi = "10.1016/j.atherosclerosis.2009.07.055",

language = "English",

volume = "31",

pages = "217 -- 221",

journal = "European Heart Journal",

issn = "1522-9645",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Endothelia response to childhood infection: The role of mannose-binding lectin (MBL)

AU - Charkida, M

AU - Donald, AE

AU - Leary, Sam D

AU - Halcox, JP

AU - Turner, MW

AU - Johson, M

AU - Loukogeorgakis, SP

AU - Davey Smith, G

AU - Okorie, MI

AU - Deanfield, JE

AU - Klein, NJ

PY - 2010/1

Y1 - 2010/1

N2 - OBJECTIVE: To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood. METHODS: We studied 2176 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. Endothelial function was assessed by flow mediated dilatation (FMD). Exon 1 and promoter polymorphisms in the MBL gene were determined by heteroduplexing procedures. Children were classified as AA (wild type) AO (heterozygotes) and OO (homozygotes). RESULTS: During the vascular assessment, 544 children presented with current or recent (

AB - OBJECTIVE: To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood. METHODS: We studied 2176 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. Endothelial function was assessed by flow mediated dilatation (FMD). Exon 1 and promoter polymorphisms in the MBL gene were determined by heteroduplexing procedures. Children were classified as AA (wild type) AO (heterozygotes) and OO (homozygotes). RESULTS: During the vascular assessment, 544 children presented with current or recent (

U2 - 10.1016/j.atherosclerosis.2009.07.055

DO - 10.1016/j.atherosclerosis.2009.07.055

M3 - Article (Academic Journal)

C2 - 19709662

SN - 1522-9645

VL - 31

SP - 217

EP - 221

JO - European Heart Journal

JF - European Heart Journal

ER -

Endothelia response to childhood infection: The role of mannose-binding lectin (MBL)

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