Endothelia response to childhood infection: The role of mannose-binding lectin (MBL)

M Charkida, AE Donald, Sam D Leary, JP Halcox, MW Turner, M Johson, SP Loukogeorgakis, G Davey Smith, MI Okorie, JE Deanfield, NJ Klein

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

OBJECTIVE: To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood. METHODS: We studied 2176 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. Endothelial function was assessed by flow mediated dilatation (FMD). Exon 1 and promoter polymorphisms in the MBL gene were determined by heteroduplexing procedures. Children were classified as AA (wild type) AO (heterozygotes) and OO (homozygotes). RESULTS: During the vascular assessment, 544 children presented with current or recent (
Translated title of the contributionEndothelia response to childhood infection: The role of mannose-binding lectin (MBL)
Original languageEnglish
Pages (from-to)217 - 221
Number of pages4
JournalEuropean Heart Journal
Volume31
DOIs
Publication statusPublished - Jan 2010

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