Endothelial cell-cell adhesion and signaling

Research output: Contribution to journalReview article (Academic Journal)peer-review

147 Citations (Scopus)
404 Downloads (Pure)


Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalExperimental Cell Research
Issue number1
Early online date8 Jun 2017
Publication statusPublished - 1 Sept 2017


  • Actins
  • Adherens Junctions
  • Animals
  • Cell Adhesion
  • Endothelial Cells
  • Humans
  • Leukocytes
  • Signal Transduction
  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't


Dive into the research topics of 'Endothelial cell-cell adhesion and signaling'. Together they form a unique fingerprint.

Cite this