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Endothelial cell-cell adhesion and signaling

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalExperimental Cell Research
Volume358
Issue number1
Early online date8 Jun 2017
DOIs
DateAccepted/In press - 2 Jun 2017
DateE-pub ahead of print - 8 Jun 2017
DatePublished (current) - 1 Sep 2017

Abstract

Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.

    Research areas

  • Actins, Adherens Junctions, Animals, Cell Adhesion, Endothelial Cells, Humans, Leukocytes, Signal Transduction, Journal Article, Review, Research Support, Non-U.S. Gov't

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Elsevier at https://doi.org/10.1016/j.yexcr.2017.06.003 . Please refer to any applicable terms of use of the publisher.

    Final published version, 789 KB, PDF document

    Licence: CC BY

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