Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species

Matthew C Gage, Nadira Y Yuldasheva, Hema Viswambharan, Piruthivi Sukumar, Richard M Cubbon, Stacey Galloway, Helen Imrie, Anna Skromna, Jessica Smith, Christopher L Jackson, Mark T Kearney, Stephen B Wheatcroft

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Abstract

Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development. We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen species.
Original languageEnglish
Pages (from-to)131-9
Number of pages9
JournalAtherosclerosis
Volume230
Issue number1
DOIs
Publication statusPublished - Sep 2013

Bibliographical note

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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