Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species

Matthew C Gage; Nadira Y Yuldasheva; Hema Viswambharan; Piruthivi Sukumar; Richard M Cubbon; Stacey Galloway; Helen Imrie; Anna Skromna; Jessica Smith; Christopher L Jackson; Mark T Kearney; Stephen B Wheatcroft

doi:10.1016/j.atherosclerosis.2013.06.017

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species

Matthew C Gage
, Nadira Y Yuldasheva
, Hema Viswambharan
, Piruthivi Sukumar
, Richard M Cubbon
, Stacey Galloway
, Helen Imrie
, Anna Skromna
, Jessica Smith
, Christopher L Jackson
, Mark T Kearney
, Stephen B Wheatcroft

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

48 Citations (Scopus)

Abstract

Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development. We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen species.

Original language	English
Pages (from-to)	131-9
Number of pages	9
Journal	Atherosclerosis
Volume	230
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2013.06.017
Publication status	Published - Sept 2013

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Gage, M. C., Yuldasheva, N. Y., Viswambharan, H., Sukumar, P., Cubbon, R. M., Galloway, S., Imrie, H., Skromna, A., Smith, J., Jackson, C. L., Kearney, M. T., & Wheatcroft, S. B. (2013). Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species. Atherosclerosis, 230(1), 131-9. https://doi.org/10.1016/j.atherosclerosis.2013.06.017

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abstract = "Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development. We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen species.",

author = "Gage, \{Matthew C\} and Yuldasheva, \{Nadira Y\} and Hema Viswambharan and Piruthivi Sukumar and Cubbon, \{Richard M\} and Stacey Galloway and Helen Imrie and Anna Skromna and Jessica Smith and Jackson, \{Christopher L\} and Kearney, \{Mark T\} and Wheatcroft, \{Stephen B\}",

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doi = "10.1016/j.atherosclerosis.2013.06.017",

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Gage, MC, Yuldasheva, NY, Viswambharan, H, Sukumar, P, Cubbon, RM, Galloway, S, Imrie, H, Skromna, A, Smith, J, Jackson, CL, Kearney, MT & Wheatcroft, SB 2013, 'Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species', Atherosclerosis, vol. 230, no. 1, pp. 131-9. https://doi.org/10.1016/j.atherosclerosis.2013.06.017

TY - JOUR

T1 - Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns

T2 - A role for reactive oxygen species

AU - Gage, Matthew C

AU - Yuldasheva, Nadira Y

AU - Viswambharan, Hema

AU - Sukumar, Piruthivi

AU - Cubbon, Richard M

AU - Galloway, Stacey

AU - Imrie, Helen

AU - Skromna, Anna

AU - Smith, Jessica

AU - Jackson, Christopher L

AU - Kearney, Mark T

AU - Wheatcroft, Stephen B

PY - 2013/9

Y1 - 2013/9

N2 - Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development. We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen species.

AB - Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development. We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen species.

U2 - 10.1016/j.atherosclerosis.2013.06.017

DO - 10.1016/j.atherosclerosis.2013.06.017

M3 - Article (Academic Journal)

C2 - 23958265

SN - 0021-9150

VL - 230

SP - 131

EP - 139

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1