Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers

Dhasni Muthumuni; Kozeta Miliku; Kaitlin H Wade; Nicholas John  Timpson; Meghan Azad

Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers

Dhasni Muthumuni, Kozeta Miliku, Kaitlin H Wade, Nicholas John Timpson, Meghan Azad^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

9 Citations (Scopus)

Abstract

Diarrhea is a major cause of infant mortality. Being a “nonsecretor” (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. Breastfeeding also protects against diarrhea; however, the impact of maternal secretor status is unknown. In the ALSPAC cohort (N = 4971), we found that breastfeeding by nonsecretor mothers was especially protective against diarrhea, which could inform new prevention strategies.

Original language	English
Pages (from-to)	260-263
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	40
Issue number	3
Publication status	Published - 1 Mar 2021

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title = "Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers",

abstract = "Diarrhea is a major cause of infant mortality. Being a “nonsecretor” (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. Breastfeeding also protects against diarrhea; however, the impact of maternal secretor status is unknown. In the ALSPAC cohort (N = 4971), we found that breastfeeding by nonsecretor mothers was especially protective against diarrhea, which could inform new prevention strategies.",

author = "Dhasni Muthumuni and Kozeta Miliku and Wade, \{Kaitlin H\} and Timpson, \{Nicholas John\} and Meghan Azad",

year = "2021",

month = mar,

day = "1",

language = "English",

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pages = "260--263",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers

AU - Muthumuni, Dhasni

AU - Miliku, Kozeta

AU - Wade, Kaitlin H

AU - Timpson, Nicholas John

AU - Azad, Meghan

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Diarrhea is a major cause of infant mortality. Being a “nonsecretor” (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. Breastfeeding also protects against diarrhea; however, the impact of maternal secretor status is unknown. In the ALSPAC cohort (N = 4971), we found that breastfeeding by nonsecretor mothers was especially protective against diarrhea, which could inform new prevention strategies.

AB - Diarrhea is a major cause of infant mortality. Being a “nonsecretor” (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. Breastfeeding also protects against diarrhea; however, the impact of maternal secretor status is unknown. In the ALSPAC cohort (N = 4971), we found that breastfeeding by nonsecretor mothers was especially protective against diarrhea, which could inform new prevention strategies.

M3 - Article (Academic Journal)

SN - 0891-3668

VL - 40

SP - 260

EP - 263

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 3

ER -

Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers

Abstract

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