Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones

H Cimarosti, E Ashikaga, N Jaafari, L Dearden, P Rubin, K.A Wilkinson, JM Henley

Research output: Contribution to journalArticle (Academic Journal)peer-review

52 Citations (Scopus)

Abstract

Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones. Surprisingly, the SUMO protease SENP-1, which removes SUMO from conjugated proteins, was also increased by OGD, suggesting that the neuronal response to OGD involves a complex interplay between SUMOylation and deSUMOylation. Importantly, decreasing global SUMOylation in cultured hippocampal neurones by overexpression of the catalytic domain of SENP-1 increased neuronal vulnerability to OGD-induced cell death. Taken together, these results suggest a neuroprotective role for neuronal SUMOylation after OGD.
Translated title of the contributionEnhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones
Original languageEnglish
Pages (from-to)17 - 22
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2012

Bibliographical note

Other: First published on-line 12th October 2011. 21989481

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