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Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones. Surprisingly, the SUMO protease SENP-1, which removes SUMO from conjugated proteins, was also increased by OGD, suggesting that the neuronal response to OGD involves a complex interplay between SUMOylation and deSUMOylation. Importantly, decreasing global SUMOylation in cultured hippocampal neurones by overexpression of the catalytic domain of SENP-1 increased neuronal vulnerability to OGD-induced cell death. Taken together, these results suggest a neuroprotective role for neuronal SUMOylation after OGD.
|Translated title of the contribution||Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones|
|Pages (from-to)||17 - 22|
|Number of pages||6|
|Journal||Journal of Cerebral Blood Flow and Metabolism|
|Publication status||Published - Jan 2012|