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Abstract
Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones. Surprisingly, the SUMO protease SENP-1, which removes SUMO from conjugated proteins, was also increased by OGD, suggesting that the neuronal response to OGD involves a complex interplay between SUMOylation and deSUMOylation. Importantly, decreasing global SUMOylation in cultured hippocampal neurones by overexpression of the catalytic domain of SENP-1 increased neuronal vulnerability to OGD-induced cell death. Taken together, these results suggest a neuroprotective role for neuronal SUMOylation after OGD.
Translated title of the contribution | Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones |
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Original language | English |
Pages (from-to) | 17 - 22 |
Number of pages | 6 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 32 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2012 |
Bibliographical note
Other: First published on-line 12th October 2011. 21989481Fingerprint
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