Enhancing the potential of enantioselective organocatalysis with light

Mattia Silvi, Paolo Melchiorre

Research output: Contribution to journalArticle (Academic Journal)peer-review

362 Downloads (Pure)

Abstract

Organocatalysis—catalysis mediated by small chiral organic molecules—is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previously inaccessible reaction pathways, thereby creating new synthetic opportunities. Here we describe the historical context, scientific reasoning and landmark discoveries that were essential in expanding the functions of organocatalysis to include one-electron-mediated chemistry and excited-state reactivity.
Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalNature
Volume554
Issue number7690
Early online date31 Jan 2018
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • Organocatalysis
  • Photochemistry

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