Enzyme Evolution and the Temperature Dependence of Enzyme Catalysis

Vickery L. Arcus*, Marc W Van Der Kamp, Christopher R Pudney, Adrian J Mulholland*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

46 Citations (Scopus)
239 Downloads (Pure)


Experiments and biomolecular simulations are revealing new and unexpected details of how enzymes are adapted to specific temperatures. These findings are elucidating enzyme evolutionary trajectories and offer great promise for design and engineering of natural and artificial enzymes. They also have implications for understanding responses of larger scale biological temperature dependence, relevant for understanding the effects of climate change on ecosystems. We review recent work on the temperature dependence of enzyme-catalysed reaction rates and the implications for enzyme evolution. Evidence from kinetic isotope effects, temperature dependent reaction rates, molecular dynamics simulations and thermodynamics provides new insights into enzyme thermoadaptation and evolution
Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalCurrent Opinion in Structural Biology
Early online date11 Jul 2020
Publication statusPublished - 1 Dec 2020


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