Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children

K Dhanalakshmi; Aishwarya Venkataraman; S Balasubramanian; Manoj Madhusudan; Sumanth Amperayani; Sulochana Putilibai; Kalaimaran Sadasivam; Bala Ramachandran; A V Ramanan

doi:10.1007/s13312-020-2025-1

Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children

K Dhanalakshmi
, Aishwarya Venkataraman^*
, S Balasubramanian
, Manoj Madhusudan
, Sumanth Amperayani
, Sulochana Putilibai
, Kalaimaran Sadasivam
, Bala Ramachandran
, A V Ramanan

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

83 Citations (Scopus)

Abstract

Background
We describe the demographic, clinical and laboratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome — Temporally associated with SARS-CoV-2 (PIMS-TS).

Methods
We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020.

Results
We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths.

Conclusion
Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.

Original language	English
Pages (from-to)	1010-1014
Number of pages	5
Journal	Indian Pediatrics
Volume	57
Issue number	11
Early online date	6 Aug 2020
DOIs	https://doi.org/10.1007/s13312-020-2025-1
Publication status	Published - 15 Nov 2020

Keywords

Adolescent
Antibodies, Monoclonal, Humanized/therapeutic use
Aspirin/therapeutic use
Blood Coagulation Disorders/etiology
C-Reactive Protein/analysis
COVID-19/diagnosis
Child
Child, Preschool
Female
Fever/etiology
Glucocorticoids/therapeutic use
Humans
Immunoglobulins, Intravenous/therapeutic use
India/epidemiology
Infant
Intensive Care Units, Pediatric
International Normalized Ratio
Male
Patient Admission/statistics & numerical data
Platelet Aggregation Inhibitors/therapeutic use
Prothrombin Time
SARS-CoV-2
Systemic Inflammatory Response Syndrome/diagnosis

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Dhanalakshmi, K., Venkataraman, A., Balasubramanian, S., Madhusudan, M., Amperayani, S., Putilibai, S., Sadasivam, K., Ramachandran, B., & Ramanan, A. V. (2020). Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children. Indian Pediatrics, 57(11), 1010-1014. https://doi.org/10.1007/s13312-020-2025-1

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title = "Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children",

abstract = "Background We describe the demographic, clinical and laboratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome — Temporally associated with SARS-CoV-2 (PIMS-TS). Methods We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020. Results We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79\%), mucocutaneous involvement (74\%), cardiovascular symptoms (63\%) and gastrointestinal symptoms (42\%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63\%) and vasoactive medications were given to 6 (31.5\%) children. There were no deaths. Conclusion Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.",

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author = "K Dhanalakshmi and Aishwarya Venkataraman and S Balasubramanian and Manoj Madhusudan and Sumanth Amperayani and Sulochana Putilibai and Kalaimaran Sadasivam and Bala Ramachandran and Ramanan, \{A V\}",

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doi = "10.1007/s13312-020-2025-1",

language = "English",

volume = "57",

pages = "1010--1014",

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Dhanalakshmi, K, Venkataraman, A, Balasubramanian, S, Madhusudan, M, Amperayani, S, Putilibai, S, Sadasivam, K, Ramachandran, B & Ramanan, AV 2020, 'Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children', Indian Pediatrics, vol. 57, no. 11, pp. 1010-1014. https://doi.org/10.1007/s13312-020-2025-1

Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children. / Dhanalakshmi, K; Venkataraman, Aishwarya; Balasubramanian, S et al.
In: Indian Pediatrics, Vol. 57, No. 11, 15.11.2020, p. 1010-1014.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children

AU - Dhanalakshmi, K

AU - Venkataraman, Aishwarya

AU - Balasubramanian, S

AU - Madhusudan, Manoj

AU - Amperayani, Sumanth

AU - Putilibai, Sulochana

AU - Sadasivam, Kalaimaran

AU - Ramachandran, Bala

AU - Ramanan, A V

PY - 2020/11/15

Y1 - 2020/11/15

N2 - Background We describe the demographic, clinical and laboratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome — Temporally associated with SARS-CoV-2 (PIMS-TS). Methods We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020. Results We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths. Conclusion Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.

AB - Background We describe the demographic, clinical and laboratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome — Temporally associated with SARS-CoV-2 (PIMS-TS). Methods We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020. Results We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths. Conclusion Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.

KW - Adolescent

KW - Antibodies, Monoclonal, Humanized/therapeutic use

KW - Aspirin/therapeutic use

KW - Blood Coagulation Disorders/etiology

KW - C-Reactive Protein/analysis

KW - COVID-19/diagnosis

KW - Child

KW - Child, Preschool

KW - Female

KW - Fever/etiology

KW - Glucocorticoids/therapeutic use

KW - Humans

KW - Immunoglobulins, Intravenous/therapeutic use

KW - India/epidemiology

KW - Infant

KW - Intensive Care Units, Pediatric

KW - International Normalized Ratio

KW - Male

KW - Patient Admission/statistics & numerical data

KW - Platelet Aggregation Inhibitors/therapeutic use

KW - Prothrombin Time

KW - SARS-CoV-2

KW - Systemic Inflammatory Response Syndrome/diagnosis

U2 - 10.1007/s13312-020-2025-1

DO - 10.1007/s13312-020-2025-1

M3 - Article (Academic Journal)

C2 - 32769230

SN - 0019-6061

VL - 57

SP - 1010

EP - 1014

JO - Indian Pediatrics

JF - Indian Pediatrics

IS - 11

ER -

Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children

Abstract

Keywords

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