Epidemiology and Genetic Epidemiology

P. R. Burton*, J. M. Bowden, M. D. Tobin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

1 Citation (Scopus)

Abstract

This chapter focuses on descriptive analysis in genetic epidemiology and some of its links with mainstream epidemiology. It starts with incidence and prevalence, briefly reviewing some of the relevant statistical methods, and then moves on to consider the analysis of correlated responses in mainstream epidemiology. The core of the chapter describes methods used in descriptive analysis in genetic epidemiology. These methods are primarily used to describe and draw inferences about the structure of phenotypic dependencies within families. The appropriate focus of traditional descriptive epidemiology on representative sampling frames and high response rates is paralleled by the equal importance of sampling schemes in descriptive genetic epidemiology and a full section is therefore devoted to non-random ascertainment.

Original languageEnglish
Title of host publicationHandbook of Statistical Genetics
Subtitle of host publicationThird Edition
PublisherJohn Wiley & Sons, Ltd.
Pages1109-1140
Number of pages32
Volume2
ISBN (Print)9780470058305
DOIs
Publication statusPublished - 9 May 2008

Keywords

  • Classical ascertainment bias
  • Dynamic allele specific hybridisation
  • Epidemiological genetics
  • First-order Markov process
  • Generalised linear mixed model and estimating equations
  • Li-Mantel estimator
  • Poisson likelihoods
  • Polygenic additive and dominance effects
  • Population-averaged interpretation

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  • Cite this

    Burton, P. R., Bowden, J. M., & Tobin, M. D. (2008). Epidemiology and Genetic Epidemiology. In Handbook of Statistical Genetics: Third Edition (Vol. 2, pp. 1109-1140). John Wiley & Sons, Ltd.. https://doi.org/10.1002/9780470061619.ch32