Abstract
Background
Few studies describe the epidemiology of childhood acute kidney injury (AKI) nationally. Laboratories in England are required to issue electronic (e-)alerts for AKI based on serum creatinine changes. This study describes a national cohort of children who received an AKI alert and their clinical course.
Methods
A cross-section of AKI episodes from 2017 are described. Hospital record linkage enabled description of AKI-associated hospitalisations including length of stay (LOS) and critical care requirement. Risk associations with critical care (hospitalised cohort) and 30-day mortality (total cohort) were examined using multivariable logistic regression.
Results
In 2017, 7 788 children (52% male, median age 4.4, IQR 0.9–11.5 years) experienced 8 927 AKI episodes; 8% occurred during birth admissions. Of 5 582 children with hospitalised AKI, 25% required critical care. In children experiencing an AKI episode unrelated to their birth admission, Asian ethnicity, young (Conclusions
Risk associations for adverse AKI outcomes differed among children according to AKI type and whether hospitalisation was related to birth. Understanding factors driving AKI development and progression may help inform interventions to minimise morbidity.
Few studies describe the epidemiology of childhood acute kidney injury (AKI) nationally. Laboratories in England are required to issue electronic (e-)alerts for AKI based on serum creatinine changes. This study describes a national cohort of children who received an AKI alert and their clinical course.
Methods
A cross-section of AKI episodes from 2017 are described. Hospital record linkage enabled description of AKI-associated hospitalisations including length of stay (LOS) and critical care requirement. Risk associations with critical care (hospitalised cohort) and 30-day mortality (total cohort) were examined using multivariable logistic regression.
Results
In 2017, 7 788 children (52% male, median age 4.4, IQR 0.9–11.5 years) experienced 8 927 AKI episodes; 8% occurred during birth admissions. Of 5 582 children with hospitalised AKI, 25% required critical care. In children experiencing an AKI episode unrelated to their birth admission, Asian ethnicity, young (Conclusions
Risk associations for adverse AKI outcomes differed among children according to AKI type and whether hospitalisation was related to birth. Understanding factors driving AKI development and progression may help inform interventions to minimise morbidity.
| Original language | English |
|---|---|
| Article number | sfad070 |
| Pages (from-to) | 1288–1297 |
| Number of pages | 10 |
| Journal | Clinical Kidney Journal |
| Volume | 16 |
| Issue number | 8 |
| Early online date | 19 Apr 2023 |
| DOIs | |
| Publication status | Published - 1 Aug 2023 |