Epigenetics: a lasting impression?

Simon C Biddie; Stafford L Lightman

doi:10.1111/j.1365-2826.2010.02082.x

Epigenetics: a lasting impression?

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Epigenetics is the term that has been classically used to describe inheritable nongenetic factors that regulate genes. Although these factors were originally thought to act in a long time domain only, it is now clear that they can also be highly dynamic, changing over minutes. Transcription factors, including the glucocorticoid, oestrogen and androgen receptors, interact with these epigenetic mechanisms in a very dynamic manner to modify transcription of genes and consequently contribute to physiological processes, health and disease. Modern usage of the term epigenetics encompasses both longer-term and transient changes and is relevant to multiple biological systems.

Original language	English
Pages (from-to)	194-5
Number of pages	2
Journal	Journal of Neuroendocrinology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2826.2010.02082.x
Publication status	Published - Feb 2011

Bibliographical note

Keywords

Epigenesis, Genetic
Epigenomics/trends
Humans
Models, Genetic
Transcription Factors/metabolism

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title = "Epigenetics: a lasting impression?",

abstract = "Epigenetics is the term that has been classically used to describe inheritable nongenetic factors that regulate genes. Although these factors were originally thought to act in a long time domain only, it is now clear that they can also be highly dynamic, changing over minutes. Transcription factors, including the glucocorticoid, oestrogen and androgen receptors, interact with these epigenetic mechanisms in a very dynamic manner to modify transcription of genes and consequently contribute to physiological processes, health and disease. Modern usage of the term epigenetics encompasses both longer-term and transient changes and is relevant to multiple biological systems.",

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note = "{\textcopyright} 2011 The Authors. Journal of Neuroendocrinology {\textcopyright} 2011 Blackwell Publishing Ltd.",

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doi = "10.1111/j.1365-2826.2010.02082.x",

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AU - Lightman, Stafford L

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AB - Epigenetics is the term that has been classically used to describe inheritable nongenetic factors that regulate genes. Although these factors were originally thought to act in a long time domain only, it is now clear that they can also be highly dynamic, changing over minutes. Transcription factors, including the glucocorticoid, oestrogen and androgen receptors, interact with these epigenetic mechanisms in a very dynamic manner to modify transcription of genes and consequently contribute to physiological processes, health and disease. Modern usage of the term epigenetics encompasses both longer-term and transient changes and is relevant to multiple biological systems.

KW - Epigenesis, Genetic

KW - Epigenomics/trends

KW - Humans

KW - Models, Genetic

KW - Transcription Factors/metabolism

U2 - 10.1111/j.1365-2826.2010.02082.x

DO - 10.1111/j.1365-2826.2010.02082.x

M3 - Article (Academic Journal)

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JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

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