Epigenetics and child health: basic principles

A Groom; H R Elliott; N D Embleton; C L Relton

doi:10.1136/adc.2009.165712

Epigenetics and child health: basic principles

A Groom, H R Elliott, N D Embleton, C L Relton

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

Abstract

Epigenetic mechanisms are believed to play an important role in disease, development and ageing with early life representing a window of particular epigenomic plasticity. The knowledge upon which these claims are based is beginning to expand. This review summarises evidence pointing to the determinants of epigenetic patterns, their juxtaposition at the interface of the environment, their influence on gene function and the relevance of this information to child health.

Original language	English
Pages (from-to)	863-9
Number of pages	7
Journal	Archives of Disease in Childhood
Volume	96
Issue number	9
DOIs	https://doi.org/10.1136/adc.2009.165712
Publication status	Published - Sept 2011

Keywords

Child
Child Development
DNA Methylation
Environment
Epigenesis, Genetic
Epigenomics
Gene Expression Regulation, Developmental
Genetic Predisposition to Disease
Genome
Humans
Phenotype

Access to Document

10.1136/adc.2009.165712

Handle.net

Persistent link

Cite this

@article{e98035b297af49028767b61c56c72e81,

title = "Epigenetics and child health: basic principles",

abstract = "Epigenetic mechanisms are believed to play an important role in disease, development and ageing with early life representing a window of particular epigenomic plasticity. The knowledge upon which these claims are based is beginning to expand. This review summarises evidence pointing to the determinants of epigenetic patterns, their juxtaposition at the interface of the environment, their influence on gene function and the relevance of this information to child health.",

keywords = "Child, Child Development, DNA Methylation, Environment, Epigenesis, Genetic, Epigenomics, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease, Genome, Humans, Phenotype",

author = "A Groom and Elliott, {H R} and Embleton, {N D} and Relton, {C L}",

year = "2011",

month = sep,

doi = "10.1136/adc.2009.165712",

language = "English",

volume = "96",

pages = "863--9",

journal = "Archives of Disease in Childhood",

issn = "0003-9888",

publisher = "BMJ Publishing Group",

number = "9",

}

TY - JOUR

T1 - Epigenetics and child health

T2 - basic principles

AU - Groom, A

AU - Elliott, H R

AU - Embleton, N D

AU - Relton, C L

PY - 2011/9

Y1 - 2011/9

N2 - Epigenetic mechanisms are believed to play an important role in disease, development and ageing with early life representing a window of particular epigenomic plasticity. The knowledge upon which these claims are based is beginning to expand. This review summarises evidence pointing to the determinants of epigenetic patterns, their juxtaposition at the interface of the environment, their influence on gene function and the relevance of this information to child health.

AB - Epigenetic mechanisms are believed to play an important role in disease, development and ageing with early life representing a window of particular epigenomic plasticity. The knowledge upon which these claims are based is beginning to expand. This review summarises evidence pointing to the determinants of epigenetic patterns, their juxtaposition at the interface of the environment, their influence on gene function and the relevance of this information to child health.

KW - Child

KW - Child Development

KW - DNA Methylation

KW - Environment

KW - Epigenesis, Genetic

KW - Epigenomics

KW - Gene Expression Regulation, Developmental

KW - Genetic Predisposition to Disease

KW - Genome

KW - Humans

KW - Phenotype

U2 - 10.1136/adc.2009.165712

DO - 10.1136/adc.2009.165712

M3 - Article (Academic Journal)

C2 - 20656732

SN - 0003-9888

VL - 96

SP - 863

EP - 869

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

IS - 9

ER -

Epigenetics and child health: basic principles

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this