Epigenetics in transgenerational responses to environmental impacts: from facts and gaps

Claudine Junien, Polina Panchenko, Sara Fneich, Luciano Pirola, Sabrina Chriett, Valérie Amarger, Bertrand Kaeffer, Patricia Parnet, Jérome Torrisani, Francisco Bolaños Jimenez, Hélène Jammes, Anne Gabory

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

The existence of non-genetic and non-cultural mechanisms that transfer information on the memory of parental exposures to various environments, determining the reactivity of the following generations to their environments during their life, are of growing interest. Yet fundamental questions remain about the nature, the roles and relative importance of epigenetic marks and processes, non-coding RNAs, or other mechanisms, and their persistence over generations. A model incorporating the various transmission systems, their cross-talks and windows of susceptibility to the environment as a function of sex/gender of parent and offspring, has yet to be built.

Translated title of the contributionEpigenetics in transgenerational responses to environmental impacts: from facts and gaps
Original languageFrench
Pages (from-to)35-44
Number of pages10
Journalmédecine/sciences
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2016

Keywords

  • DNA Methylation
  • Disease Susceptibility
  • Environment
  • Epigenesis, Genetic
  • Family Characteristics
  • Female
  • Gene-Environment Interaction
  • Humans
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • RNA, Untranslated
  • Journal Article
  • Review

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