Epstein-Barr virus and Burkitt lymphoma

G Brady, G J MacArthur, P J Farrell

Research output: Contribution to journalArticle (Academic Journal)

118 Citations (Scopus)

Abstract

Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. Epstein-Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review.
Original languageEnglish
Pages (from-to)1397-402
Number of pages6
JournalJournal of Clinical Pathology
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Burkitt Lymphoma
  • Cell Proliferation
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Genes, myc
  • Herpesvirus 4, Human
  • Humans
  • Malaria
  • Translocation, Genetic

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