Projects per year
Abstract
Metazoans require efficient and ordered secretion of extracellular matrix (ECM) to coordinate cell and tissue function. Many ECM proteins are atypically large and their demand during key stages of development presents a major challenge to the canonical secretion machinery. While many of the molecular players in this pathway are known, little is understood about how they are integrated in time and space. Recent advances in gene engineering and super-resolution microscopy have underscored the spatiotemporal organisation of the endoplasmic reticulum (ER)–Golgi interface. These findings are challenging long-held models of vesicular transport of large matrix proteins, such as procollagen, and are implicating less well-defined carriers and direct interconnections between organelles. Here, we discuss current models describing the dynamics and mechanisms of ER–Golgi transport.
Original language | English |
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Pages (from-to) | 940-953 |
Number of pages | 14 |
Journal | Trends in Cell Biology |
Volume | 29 |
Issue number | 12 |
Early online date | 17 Oct 2019 |
DOIs | |
Publication status | Published - 1 Dec 2019 |
Keywords
- COPII
- vesicle
- endoplasmic reticulum
- Golgi
- collagen
- trafficking
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Dive into the research topics of 'ER-to-Golgi Transport: A Sizeable Problem'. Together they form a unique fingerprint.Projects
- 2 Finished
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High-resolution imaging and time-resolved proteomic profiling of COPII-dependent procollagen packaging.
Stephens, D. J. (Principal Investigator)
4/11/16 → 31/12/19
Project: Research
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The dynein-2 microtubule motor
Stephens, D. J. (Principal Investigator)
11/01/16 → 10/01/19
Project: Research