ER-to-Golgi Transport: A Sizeable Problem

Janine McCaughey, David J. Stephens*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)

4 Citations (Scopus)

Abstract

Metazoans require efficient and ordered secretion of extracellular matrix (ECM) to coordinate cell and tissue function. Many ECM proteins are atypically large and their demand during key stages of development presents a major challenge to the canonical secretion machinery. While many of the molecular players in this pathway are known, little is understood about how they are integrated in time and space. Recent advances in gene engineering and super-resolution microscopy have underscored the spatiotemporal organisation of the endoplasmic reticulum (ER)–Golgi interface. These findings are challenging long-held models of vesicular transport of large matrix proteins, such as procollagen, and are implicating less well-defined carriers and direct interconnections between organelles. Here, we discuss current models describing the dynamics and mechanisms of ER–Golgi transport.

Original languageEnglish
Pages (from-to)940-953
Number of pages14
JournalTrends in Cell Biology
Volume29
Issue number12
Early online date17 Oct 2019
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • COPII
  • vesicle
  • endoplasmic reticulum
  • Golgi
  • collagen
  • trafficking

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