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ER-to-Golgi Transport: A Sizeable Problem

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)940-953
Number of pages14
JournalTrends in Cell Biology
Volume29
Issue number12
Early online date17 Oct 2019
DOIs
DateAccepted/In press - 13 Oct 2019
DateE-pub ahead of print - 17 Oct 2019
DatePublished (current) - 1 Dec 2019

Abstract

Metazoans require efficient and ordered secretion of extracellular matrix (ECM) to coordinate cell and tissue function. Many ECM proteins are atypically large and their demand during key stages of development presents a major challenge to the canonical secretion machinery. While many of the molecular players in this pathway are known, little is understood about how they are integrated in time and space. Recent advances in gene engineering and super-resolution microscopy have underscored the spatiotemporal organisation of the endoplasmic reticulum (ER)–Golgi interface. These findings are challenging long-held models of vesicular transport of large matrix proteins, such as procollagen, and are implicating less well-defined carriers and direct interconnections between organelles. Here, we discuss current models describing the dynamics and mechanisms of ER–Golgi transport.

    Research areas

  • COPII, vesicle, endoplasmic reticulum, Golgi, collagen, trafficking

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Documents

  • Full-text PDF (author’s accepted manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S0962892419301436#! . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 3.35 MB, PDF document

    Embargo ends: 17/10/20

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    Licence: CC BY-NC-ND

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