TY - JOUR
T1 - Erythrocyte Sedimentation
T2 - Collapse of a High-Volume-Fraction Soft-Particle Gel
AU - Darras, Alexis
AU - Dasanna, Anil Kumar
AU - John, Thomas
AU - Gompper, Gerhard
AU - Kaestner, Lars
AU - Fedosov, Dmitry A.
AU - Wagner, Christian
N1 - Publisher Copyright:
© 2022 American Physical Society.
PY - 2022/2/25
Y1 - 2022/2/25
N2 - The erythrocyte sedimentation rate is one of the oldest medical diagnostic methods whose physical mechanisms remain debatable today. Using both light microscopy and mesoscale cell-level simulations, we show that erythrocytes form a soft-particle gel. Furthermore, the high volume fraction of erythrocytes, their deformability, and weak attraction lead to unusual properties of this gel. A theoretical model for the gravitational collapse is developed, whose predictions are in agreement with detailed macroscopic measurements of the interface velocity.
AB - The erythrocyte sedimentation rate is one of the oldest medical diagnostic methods whose physical mechanisms remain debatable today. Using both light microscopy and mesoscale cell-level simulations, we show that erythrocytes form a soft-particle gel. Furthermore, the high volume fraction of erythrocytes, their deformability, and weak attraction lead to unusual properties of this gel. A theoretical model for the gravitational collapse is developed, whose predictions are in agreement with detailed macroscopic measurements of the interface velocity.
UR - http://www.scopus.com/inward/record.url?scp=85125596552&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.128.088101
DO - 10.1103/PhysRevLett.128.088101
M3 - Article (Academic Journal)
C2 - 35275655
AN - SCOPUS:85125596552
SN - 0031-9007
VL - 128
JO - Physical Review Letters
JF - Physical Review Letters
IS - 8
M1 - 088101
ER -