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Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalPsychology, Health & Medicine
Issue numberSup1
Early online date9 Aug 2018
DateAccepted/In press - 17 Jul 2018
DateE-pub ahead of print - 9 Aug 2018
DatePublished (current) - 2018


Thyroid eye disease (TED) is a potentially sight-threatening and cosmeticallydisfiguring condition arising in 25–50% of patients with Graves’hyperthyroidism. CIRTED is the first study to evaluate the long-term role of radiotherapy and prolonged immunosuppression with azathioprine in treating TED, one aim of which was to validate the use of the English version of GO-QOL in an UK population with TED. In a three stage design over a 48 week period, the GO-QOL was tested and compared to a general measure of quality of life (WHOQOL-Bref). In stage 1 utilising a standard 14 day test-retest design both GO-QOLsubscales achieved Cronbach’s alphas demonstrating excellent validity and internal reliability (Visual Function 0.929 and 0.931; Appearance0.888 and 0.906). In stage 2, Repeated Measures ANOVA demonstrated longitudinal validity, with both subscales of the GO-QOL showing significant change over time (Visual Function, η2 = 0.114, p < .001;Appearance, η2 = 0.069, p < .002). In stage 3 the GO-QOL showed discriminant validity at the week 48 time point,with the visual function subscale being able to detect changes in groups identified by clinicians (using BCCOM ratings of improvement or deterioration), while both subscales could detect group differences when based on participants’subjective ratings of TED noticeability and severity. The results of this project provide support for the English translation of the GO-QOL as an outcome measure for patients with moderately severe active Graves’ orbitopathy/TED.

    Research areas

  • Thyroid eye disease (TED), Graves ophthalmopathy (GO), GO-QOL, adults, Psychometrics, Reliability, validity

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Taylor and Francis Online at Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 534 KB, PDF document


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