Estimating the contribution of key populations towards HIV transmission in South Africa

Jack Stone*, Christinah Mukandavire, Marie-Claude Boily, Hannah Fraser, Sharmistha Mishra, Sheree Schwartz, Amrita Rao, Katharine J Looker, Matthew Quaife, Fern Terris-Prestholt, Alexander Marr, Tim Lane, Jenny Coetzee, Harry Hausler, Katherine Young, Mfezi Mcingana, Manezi Ncedani, Adrien Puren, Gillian Hunt, Zamakayise KoseNancy Phaswana-Mafuya, Stefan D. Baral, Peter T Vickerman

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Introduction
In generalised epidemic settings, there is insufficient understanding of how the unmet HIV prevention and treatment needs of key populations (KPs), such as female sex workers (FSWs) and men who have sex with men (MSM), contribute to HIV transmission. In such settings, it is typically assumed that HIV transmission is driven by the general population. We estimated the contribution of commercial sex, sex between men, and other heterosexual partnerships to HIV transmission in South Africa (SA).

Methods
We developed the “Key-Pop Model”; a dynamic transmission model of HIV among FSWs, their clients, MSM, and the broader population in SA. The model was parameterised and calibrated using demographic, behavioural and epidemiological data from national household surveys and KP surveys. We estimated the contribution of commercial sex, sex between men, and sex among heterosexual partnerships of different sub-groups to HIV transmission over 2009-2019. We also estimated the efficiency (HIV infections averted per person-year of intervention) and prevented fraction (%IA) over 10-years from scaling-up ART (to 81% coverage) in different sub-populations from 2020.

Results
Sex between FSWs and their paying clients, and between clients with their non-paying partners contributed 6.9% (95% credibility interval 4.5-9.3%) and 41.9% (35.1-53.2%) of new HIV infections in SA over 2009-2019, respectively. Sex between low-risk groups contributed 59.7% (47.6-68.5%), sex between men contributed 5.3% (2.3-14.1%) and sex between MSM and their female partners contributed 3.7% (1.6-9.8%). Going forward, the largest population-level impact on HIV transmission can be achieved from scaling up ART to clients of FSWs (%IA=18.2% (14.0-24.4%) or low-risk individuals (%IA=20.6% (14.7-27.5) over 2020-2030), with ART scale-up among KPs being most efficient.

Conclusions
Clients of FSWs play a fundamental role in HIV transmission in SA. Addressing the HIV prevention and treatment needs of KPs in generalized HIV epidemics is central to a comprehensive HIV response.
Original languageEnglish
JournalJournal of the International AIDS Society
Publication statusAccepted/In press - 12 Nov 2020

Keywords

  • Mathematical modelling
  • population attributable fraction
  • key populations
  • female sex workers
  • clients
  • men who have sex with men

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