Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis

S L Hulin-Curtis; J L Bidwell; M J Perry

doi:10.1111/j.1744-313X.2011.01060.x

Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis

S L Hulin-Curtis, J L Bidwell, M J Perry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

Abstract

We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.

Original language	English
Pages (from-to)	106-9
Number of pages	4
Journal	International Journal of Immunogenetics
Volume	39
Issue number	2
DOIs	https://doi.org/10.1111/j.1744-313X.2011.01060.x
Publication status	Published - Apr 2012

Bibliographical note

Keywords

Alleles
Case-Control Studies
Chromosomes, Human
European Continental Ancestry Group
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Testing
Genome, Human
Haplotypes
Humans
Interleukin-18
Interleukin-18 Receptor alpha Subunit
Male
Middle Aged
Osteoarthritis, Knee
Polymorphism, Single Nucleotide
Promoter Regions, Genetic

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title = "Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis",

abstract = "We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.",

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T1 - Evaluation of IL18 and IL18R1 polymorphisms

T2 - genetic susceptibility to knee osteoarthritis

AU - Hulin-Curtis, S L

AU - Bidwell, J L

AU - Perry, M J

PY - 2012/4

Y1 - 2012/4

N2 - We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.

AB - We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.

KW - Alleles

KW - Case-Control Studies

KW - Chromosomes, Human

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genome, Human

KW - Haplotypes

KW - Humans

KW - Interleukin-18

KW - Interleukin-18 Receptor alpha Subunit

KW - Male

KW - Middle Aged

KW - Osteoarthritis, Knee

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

U2 - 10.1111/j.1744-313X.2011.01060.x

DO - 10.1111/j.1744-313X.2011.01060.x

M3 - Article (Academic Journal)

C2 - 22136483

VL - 39

SP - 106

EP - 109

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

SN - 1744-3121

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