Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis

S L Hulin-Curtis, J L Bidwell, M J Perry

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.
Original languageEnglish
Pages (from-to)106-9
Number of pages4
JournalInternational Journal of Immunogenetics
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 2012

Bibliographical note

© 2011 Blackwell Publishing Ltd.

Keywords

  • Alleles
  • Case-Control Studies
  • Chromosomes, Human
  • European Continental Ancestry Group
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetic Testing
  • Genome, Human
  • Haplotypes
  • Humans
  • Interleukin-18
  • Interleukin-18 Receptor alpha Subunit
  • Male
  • Middle Aged
  • Osteoarthritis, Knee
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic

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