Abstract
We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.
Original language | English |
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Pages (from-to) | 106-9 |
Number of pages | 4 |
Journal | International Journal of Immunogenetics |
Volume | 39 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2012 |
Bibliographical note
© 2011 Blackwell Publishing Ltd.Keywords
- Alleles
- Case-Control Studies
- Chromosomes, Human
- European Continental Ancestry Group
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing
- Genome, Human
- Haplotypes
- Humans
- Interleukin-18
- Interleukin-18 Receptor alpha Subunit
- Male
- Middle Aged
- Osteoarthritis, Knee
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic