Evaluation of UW solution in a rat kidney preservation model. I. Effect of hydroxyethyl starch and electrolyte composition

M Biguzas, P Jablonski, A C Thomas, K Walls, B O Howden, D F Scott, V C Marshall

Research output: Contribution to journalArticle (Academic Journal)peer-review

37 Citations (Scopus)

Abstract

Preservation of rat kidneys by simple ice-storage has been demonstrated after 48 hr using the University of Wisconsin (UW) solution; hypothermic preservation of the rat kidney was dramatically improved. A modified UW solution without hydroxyethyl starch (HES) also gave uniform survival after 48 hr of storage, and even better function and morphology. Substitution of HES from another source also improved renal function when compared with UW (Dupont) and it is suggested that prolonged storage of UW solution prior to use may reduce its effectiveness. Reversing the Na:K ratio of the solution still allowed successful preservation, but significantly worsened morphology of the surviving kidney.

Original languageEnglish
Pages (from-to)872-5
Number of pages4
JournalTransplantation
Volume49
Issue number5
Publication statusPublished - May 1990

Keywords

  • Adenosine
  • Allopurinol
  • Animals
  • Creatinine
  • Electrolytes
  • Glutathione
  • Hydroxyethyl Starch Derivatives
  • Insulin
  • Kidney Transplantation
  • Nephritis, Interstitial
  • Organ Preservation
  • Organ Preservation Solutions
  • Raffinose
  • Rats
  • Rats, Inbred Strains
  • Solutions
  • Starch
  • Urea

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