Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis

Bethan A Brown; Helen Williams; Sarah J George

doi:10.1016/bs.pmbts.2017.01.004

Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis

Bethan A Brown, Helen Williams, Sarah J George

Bristol Medical School (THS)

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

57 Citations (Scopus)

Abstract

Atherosclerosis leads to blockage of arteries, culminating in myocardial infarction, and stroke. The involvement of matrix-degrading metalloproteinases (MMPs) in atherosclerosis is established and many studies have highlighted the importance of various MMPs in this process. MMPs were first implicated in atherosclerosis due to their ability to degrade extracellular matrix components, which can lead to increased plaque instability. However, more recent work has highlighted a multitude of roles for MMPs in addition to breakdown of extracellular matrix proteins. MMPs are now known to be involved in various stages of plaque progression: from initial macrophage infiltration to plaque rupture. This chapter summarizes the development and progression of atherosclerotic plaques and the contribution of MMPs. We provide data from human studies showing the effect of MMP polymorphisms and the expression of MMPs in both the atherosclerotic plaque and within plasma. We also discuss work in animal models of atherosclerosis that show the effect of gain or loss of function of MMPs. Together, the data provided from these studies illustrate that MMPs are ideal targets as both biomarkers and potential drug therapies for atherosclerosis.

Original language	English
Title of host publication	Matrix Metalloproteinases and Tissue Remodeling in Health and Disease
Subtitle of host publication	Cardiovascular Remodeling
Editors	Raouf Khalil
Publisher	Academic Press
Pages	197-237
Number of pages	41
Edition	1st edition
ISBN (Electronic)	9780128116388
ISBN (Print)	9780128116371
DOIs	https://doi.org/10.1016/bs.pmbts.2017.01.004
Publication status	Published - 17 Apr 2017

Publication series

Name	Progress in Molecular Biology and Translational Science
Publisher	Elsevier
Volume	147

Keywords

Animals
Atherosclerosis
Disease Models, Animal
Humans
Matrix Metalloproteinases
Models, Biological
Journal Article
Review

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Brown, B. A., Williams, H., & George, S. J. (2017). Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis. In R. Khalil (Ed.), Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling (1st edition ed., pp. 197-237). (Progress in Molecular Biology and Translational Science; Vol. 147). Academic Press. https://doi.org/10.1016/bs.pmbts.2017.01.004

Brown, Bethan A ; Williams, Helen ; George, Sarah J. / Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis. Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling. editor / Raouf Khalil. 1st edition. ed. Academic Press, 2017. pp. 197-237 (Progress in Molecular Biology and Translational Science).

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abstract = "Atherosclerosis leads to blockage of arteries, culminating in myocardial infarction, and stroke. The involvement of matrix-degrading metalloproteinases (MMPs) in atherosclerosis is established and many studies have highlighted the importance of various MMPs in this process. MMPs were first implicated in atherosclerosis due to their ability to degrade extracellular matrix components, which can lead to increased plaque instability. However, more recent work has highlighted a multitude of roles for MMPs in addition to breakdown of extracellular matrix proteins. MMPs are now known to be involved in various stages of plaque progression: from initial macrophage infiltration to plaque rupture. This chapter summarizes the development and progression of atherosclerotic plaques and the contribution of MMPs. We provide data from human studies showing the effect of MMP polymorphisms and the expression of MMPs in both the atherosclerotic plaque and within plasma. We also discuss work in animal models of atherosclerosis that show the effect of gain or loss of function of MMPs. Together, the data provided from these studies illustrate that MMPs are ideal targets as both biomarkers and potential drug therapies for atherosclerosis.",

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Brown, BA, Williams, H & George, SJ 2017, Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis. in R Khalil (ed.), Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling. 1st edition edn, Progress in Molecular Biology and Translational Science, vol. 147, Academic Press, pp. 197-237. https://doi.org/10.1016/bs.pmbts.2017.01.004

Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis. / Brown, Bethan A; Williams, Helen ; George, Sarah J.
Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling. ed. / Raouf Khalil. 1st edition. ed. Academic Press, 2017. p. 197-237 (Progress in Molecular Biology and Translational Science; Vol. 147).

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

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AU - Williams, Helen

AU - George, Sarah J

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N2 - Atherosclerosis leads to blockage of arteries, culminating in myocardial infarction, and stroke. The involvement of matrix-degrading metalloproteinases (MMPs) in atherosclerosis is established and many studies have highlighted the importance of various MMPs in this process. MMPs were first implicated in atherosclerosis due to their ability to degrade extracellular matrix components, which can lead to increased plaque instability. However, more recent work has highlighted a multitude of roles for MMPs in addition to breakdown of extracellular matrix proteins. MMPs are now known to be involved in various stages of plaque progression: from initial macrophage infiltration to plaque rupture. This chapter summarizes the development and progression of atherosclerotic plaques and the contribution of MMPs. We provide data from human studies showing the effect of MMP polymorphisms and the expression of MMPs in both the atherosclerotic plaque and within plasma. We also discuss work in animal models of atherosclerosis that show the effect of gain or loss of function of MMPs. Together, the data provided from these studies illustrate that MMPs are ideal targets as both biomarkers and potential drug therapies for atherosclerosis.

AB - Atherosclerosis leads to blockage of arteries, culminating in myocardial infarction, and stroke. The involvement of matrix-degrading metalloproteinases (MMPs) in atherosclerosis is established and many studies have highlighted the importance of various MMPs in this process. MMPs were first implicated in atherosclerosis due to their ability to degrade extracellular matrix components, which can lead to increased plaque instability. However, more recent work has highlighted a multitude of roles for MMPs in addition to breakdown of extracellular matrix proteins. MMPs are now known to be involved in various stages of plaque progression: from initial macrophage infiltration to plaque rupture. This chapter summarizes the development and progression of atherosclerotic plaques and the contribution of MMPs. We provide data from human studies showing the effect of MMP polymorphisms and the expression of MMPs in both the atherosclerotic plaque and within plasma. We also discuss work in animal models of atherosclerosis that show the effect of gain or loss of function of MMPs. Together, the data provided from these studies illustrate that MMPs are ideal targets as both biomarkers and potential drug therapies for atherosclerosis.

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KW - Disease Models, Animal

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KW - Matrix Metalloproteinases

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Brown BA, Williams H , George SJ. Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis. In Khalil R, editor, Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling. 1st edition ed. Academic Press. 2017. p. 197-237. (Progress in Molecular Biology and Translational Science). Epub 2017 Mar 3. doi: 10.1016/bs.pmbts.2017.01.004

Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis

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