Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems

Gavin Hazell, Thomas Arnold, Robert Barker, Luke Clifton, Nina-Juliane Steinke, Cecilia Tognoloni, Karen Edler

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Styrene-alt-maleic Acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs, including the potential to control lipid composition within nanodiscs containing membrane proteins.
Original languageEnglish
Pages (from-to)11845–11853
Number of pages9
JournalLangmuir
Volume32
Issue number45
Early online date14 Oct 2016
DOIs
Publication statusPublished - 15 Nov 2016

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