TY - JOUR
T1 - Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems
AU - Hazell, Gavin
AU - Arnold, Thomas
AU - Barker, Robert
AU - Clifton, Luke
AU - Steinke, Nina-Juliane
AU - Tognoloni, Cecilia
AU - Edler, Karen
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Styrene-alt-maleic Acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs, including the potential to control lipid composition within nanodiscs containing membrane proteins.
AB - Styrene-alt-maleic Acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs, including the potential to control lipid composition within nanodiscs containing membrane proteins.
U2 - 10.1021/acs.langmuir.6b02927
DO - 10.1021/acs.langmuir.6b02927
M3 - Article (Academic Journal)
C2 - 27739678
SN - 0743-7463
VL - 32
SP - 11845
EP - 11853
JO - Langmuir
JF - Langmuir
IS - 45
ER -