Evolution of eukaryotic genome architecture: Insights from the study of a rapidly evolving metazoan, Oikopleura dioica: Non-adaptive forces such as elevated mutation rates may influence the evolution of genome architecture

Sreenivas Chavali, David A de Lima Morais, Julian Gough, M Madan Babu

Research output: Contribution to journalReview article (Academic Journal)

Abstract

Recent sequencing of the metazoan Oikopleura dioica genome has provided important insights, which challenges the current understanding of eukaryotic genome evolution. Many genomic features of O. dioica show deviation from the commonly observed trends in other eukaryotic genomes. For instance, O. dioica has a rapidly evolving, highly compact genome with a divergent intron-exon organization. Additionally, O. dioica lacks the minor spliceosome and key DNA repair pathway genes. Even with a compact genome, O. dioica contains tandem repeats, comparable to other eukaryotes, and shows lineage-specific expansion of certain protein domains. Here, we review its genomic features in the context of current knowledge, discuss implications for contemporary biology and identify areas for further research. Analysis of the O. dioica genome suggests that non-adaptive forces such as elevated mutation rates might influence the evolution of genome architecture. The knowledge of unique genomic features and splicing mechanisms in O. dioica may be exploited for synthetic biology applications, such as generation of orthogonal splicing systems.

Original languageEnglish
Pages (from-to)592-601
Number of pages10
JournalBioEssays
Volume33
Issue number8
DOIs
Publication statusPublished - Aug 2011

Bibliographical note

Copyright © 2011 WILEY Periodicals, Inc.

Structured keywords

  • Bristol BioDesign Institute

Keywords

  • Animals
  • DNA Transposable Elements
  • Evolution, Molecular
  • Gene Duplication
  • Gene Order
  • Introns
  • Mutation
  • Phylogeny
  • RNA Splicing
  • RNA, Untranslated/genetics
  • Spliceosomes/genetics
  • Tandem Repeat Sequences
  • Transcription, Genetic
  • Urochordata/classification
  • SYNTHETIC BIOLOGY

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