Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.

Harriet Lane-Serff; Paula Macgregor; Lori Peacock; Olivia Macleod; Christopher Kay; Wendy Gibson; M Higgins; Mark Carrington

doi:10.7554/eLife.13044

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.

Harriet Lane-Serff, Paula Macgregor, Lori Peacock, Olivia Macleod, Christopher Kay, Wendy Gibson, M Higgins, Mark Carrington

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense receptor in complex with haemoglobin. This allows us to propose an evolutionary history for this receptor, charting the structural and cellular changes that took place as it adapted from a role in the insect to a new role in the mammalian host.

Original language	English
Article number	e13044
Number of pages	20
Journal	eLife
Volume	5
DOIs	https://doi.org/10.7554/eLife.13044
Publication status	Published - 15 Apr 2016

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Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor
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Sexual reproduction in the livestock pathogen Trypanosoma congolense
Gibson, W. C. (Principal Investigator)
1/04/15 → 31/03/18
Project: Research

Emeritus Professor Wendy C Gibson
- W.Gibsonbristol.acuk
- School of Biological Sciences - Emeritus Professor
- Cabot Institute for the Environment
- Evolutionary Biology
- Plant and Agricultural Sciences
Person: Member, Honorary and Visiting Academic

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title = "Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.",

abstract = "The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense receptor in complex with haemoglobin. This allows us to propose an evolutionary history for this receptor, charting the structural and cellular changes that took place as it adapted from a role in the insect to a new role in the mammalian host.",

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AU - Macgregor, Paula

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AU - Macleod, Olivia

AU - Kay, Christopher

AU - Gibson, Wendy

AU - Higgins, M

AU - Carrington, Mark

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AB - The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense receptor in complex with haemoglobin. This allows us to propose an evolutionary history for this receptor, charting the structural and cellular changes that took place as it adapted from a role in the insect to a new role in the mammalian host.

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JO - eLife

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M1 - e13044

ER -

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.

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Sexual reproduction in the livestock pathogen Trypanosoma congolense

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Emeritus Professor Wendy C Gibson

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