Examination of potential novel biochemical factors in relation to prostate cancer incidence and mortality in UK Biobank

Aurora Perez-Cornago*, Georgina K Fensom, Colm Andrews, Eleanor L Watts, Naomi E Allen, Richard M Martin, Mieke Van Hemelrijck, Timothy J. Key, Ruth C Travis

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Background
Although prostate cancer is a leading cause of cancer death, its aetiology is not well understood. We aimed to identify novel biochemical factors for prostate cancer incidence and mortality in UK Biobank.

Methods
A range of cardiovascular, bone, joint, diabetes, renal and liver-related biomarkers were measured in baseline blood samples collected from up to 211,754 men at recruitment and in a subsample 5 years later. Participants were followed-up via linkage to health administrative datasets to identify prostate cancer cases. Hazard ratios (HRs) and 95% confidence intervals were calculated using multivariable-adjusted Cox regression corrected for regression dilution bias. Multiple testing was accounted for by using a false discovery rate controlling procedure.

Results
After an average follow-up of 6.9 years, 5763 prostate cancer cases and 331 prostate cancer deaths were ascertained. Prostate cancer incidence was positively associated with circulating vitamin D, urea and phosphate concentrations and inversely associated with glucose, total protein and aspartate aminotransferase. Phosphate and cystatin-C were the only biomarkers positively and inversely, respectively, associated with risk in analyses excluding the first 4 years of follow-up. There was little evidence of associations with prostate cancer death.

Conclusion
We found novel associations of several biomarkers with prostate cancer incidence. Future research will examine associations by tumour characteristics.
Original languageEnglish
Pages (from-to)1808–1817 (2020)
Number of pages10
JournalBritish Journal of Cancer
Volume123
DOIs
Publication statusPublished - 23 Sep 2020

Structured keywords

  • ICEP

Keywords

  • biomarkers
  • prostate cancer
  • cohort study
  • prospective
  • metabolism

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