Abstract
Background
Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipient phase of dementia ascribed to diminished self-care, including sub-optimal nutrition, would have the effect of generating such an inverse association. One approach to circumventing this problem would be to measure weight in a population which is young enough to be free of the symptoms of dementia which is then followed up for dementia occurrence over many decades.
Methods
In a prospective cohort study, body mass index, and other potential risk factors, were measured in 9547 male university undergraduates (mean age 20.5 years) in 1948–68 who were then linked to national mortality registers.
Results
Of 2537 deaths over a mean of 50.6 years follow up, 140 were ascribed to dementia. There was no association between overweight and future dementia deaths (age-adjusted hazard ratio; 95 % confidence interval: 0.93; 0.49, 1.79).
Conclusion
In this cohort study of former university students, being overweight in youth did not confer protection against later dementia death.
Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipient phase of dementia ascribed to diminished self-care, including sub-optimal nutrition, would have the effect of generating such an inverse association. One approach to circumventing this problem would be to measure weight in a population which is young enough to be free of the symptoms of dementia which is then followed up for dementia occurrence over many decades.
Methods
In a prospective cohort study, body mass index, and other potential risk factors, were measured in 9547 male university undergraduates (mean age 20.5 years) in 1948–68 who were then linked to national mortality registers.
Results
Of 2537 deaths over a mean of 50.6 years follow up, 140 were ascribed to dementia. There was no association between overweight and future dementia deaths (age-adjusted hazard ratio; 95 % confidence interval: 0.93; 0.49, 1.79).
Conclusion
In this cohort study of former university students, being overweight in youth did not confer protection against later dementia death.
| Original language | English |
|---|---|
| Article number | 19 |
| Number of pages | 5 |
| Journal | Journal of Negative Results in Biomedicine |
| Volume | 15 |
| DOIs | |
| Publication status | Published - 2 Nov 2016 |
Keywords
- Obesity
- overweight
- dementia
- risk factors
- epidemiology
- cohort
- life course
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This is the final published version of the article (version of record). It first appeared online via BioMed Central at http://jnrbm.biomedcentral.com/articles/10.1186/s12952-016-0062-z. Please refer to any applicable terms of use of the publisher.