Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats

Hidefumi Waki, Emma B Hendy, Charlie C T Hindmarch, Sabine Gouraud, Marie Toward, Sergey Kasparov, David Murphy, Julian F R Paton

Research output: Contribution to journalArticle (Academic Journal)peer-review

33 Citations (Scopus)

Abstract

Inflammation within the brain stem microvasculature has been associated with chronic cardiovascular diseases. We found that the expression of several enzymes involved in arachidonic acid-leukotriene B4 (LTB4) production was altered in nucleus tractus solitarii (NTS) of spontaneously hypertensive rat (SHR). LTB4 produced from arachidonic acid by 5-lipoxygenase is a potent chemoattractant of leukocytes. Leukotriene B4-12-hydroxydehydrogenase (LTB4-12-HD), which degrades LTB4, was downregulated in SHR rats compared with that in Wistar-Kyoto rats. Quantitative real-time PCR revealed that LTB4-12-HD was reduced by 63% and 58% in the NTS of adult SHR and prehypertensive SHR, respectively, compared with that in age-matched Wistar-Kyoto rats (n=6). 5-lipoxygenase gene expression was upregulated in the NTS of SHR (≈50%; n=6). LTB4 levels were increased in the NTS of the SHR, (17%; n=10, P
Original languageEnglish
Pages (from-to)194-201
Number of pages14
JournalHypertension
Volume61
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • brain stem
  • hypertension
  • inflammation
  • sympathetic nervous system
  • CALCIUM IONOPHORE A23187
  • ANGIOTENSIN-II
  • NEUROGENIC HYPERTENSION
  • VASCULAR INFLAMMATION
  • ENDOTHELIAL-CELLS
  • ARACHIDONIC-ACID
  • BRAIN
  • RECEPTOR
  • ACTIVATION
  • LEUKOCYTES

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