Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum. Annals of the New York Academy of Sciences

W J Lederer, J R Berlin, N M Cohen, R W Hadley, D M Bers, M B Cannell

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Abstract

Experimental data do not support the idea that excitation-contraction coupling in heart muscle can be explained by a simple calcium-induced calcium release mechanism alone or a simple voltage-dependent calcium release mechanism alone. Our data on excitation-contraction coupling combined with the results of others suggest the need to either develop more complex and more sophisticated single-mechanism models, or to establish dual-control models.
Original languageEnglish
Pages (from-to)190-206
Number of pages17
JournalAnnals of the New York Academy of Sciences
Volume588
Issue number1 Embryonic Ori
Publication statusPublished - 1 Jan 1990

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