Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors

Ash Evans, Sonam Gurung, Jeremy Henley, Yasuko Nakamura, Kevin Wilkinson

Research output: Contribution to journalReview article (Academic Journal)peer-review

16 Citations (Scopus)
309 Downloads (Pure)

Abstract

Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.
Original languageEnglish
Pages (from-to)572-584
Number of pages13
JournalNeurochemical Research
Volume44
Issue number3
Early online date21 Dec 2017
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • Kainate receptors
  • GluK2
  • Trafficking
  • RUSH
  • Synaptic transmission
  • Synaptic plasticity
  • Humans
  • Protein Transport/physiology
  • Receptors, Kainic Acid/metabolism
  • Animals
  • Membrane Proteins/metabolism
  • Neurons/metabolism
  • Neuronal Plasticity/physiology
  • Brain/metabolism

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