Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

Jens Atzrodt; Volker Derdau; William Kerr; Marc Reid; Patrick Rojahn; Remo Weck

doi:10.1016/j.tet.2015.02.029

Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

Jens Atzrodt, Volker Derdau, William Kerr, Marc Reid, Patrick Rojahn, Remo Weck

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

42 Citations (Scopus)

Abstract

An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series

Original language	English
Journal	Tetrahedron
DOIs	https://doi.org/10.1016/j.tet.2015.02.029
Publication status	Published - 1 Apr 2015

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10.1016/j.tet.2015.02.029

https://pureportal-staging.strath.ac.uk/en/publications/18122c5b-1530-45c3-8d2e-182a19a34b66

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title = "Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles",

abstract = "An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series",

author = "Jens Atzrodt and Volker Derdau and William Kerr and Marc Reid and Patrick Rojahn and Remo Weck",

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AU - Atzrodt, Jens

AU - Derdau, Volker

AU - Kerr, William

AU - Reid, Marc

AU - Rojahn, Patrick

AU - Weck, Remo

PY - 2015/4/1

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N2 - An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series

AB - An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series

UR - https://pureportal-staging.strath.ac.uk/en/publications/18122c5b-1530-45c3-8d2e-182a19a34b66

U2 - 10.1016/j.tet.2015.02.029

DO - 10.1016/j.tet.2015.02.029

M3 - Article (Academic Journal)

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