Exploiting biosynthetic pathways in fungi: opportunities for enhanced or novel production

Kate de Mattos-Shipley, Andrew M. Bailey

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Abstract

Fungi have long been known to produce secondary metabolites, many having already been exploited as pharmaceuticals or as agrochemicals, however conventional screening for novel products declined in popularity over the last twenty years or so. With increased demand for novel antibiotics coupled with the recent revolutions in the ease of genome sequencing, there has been a resurgence in interest in fungi as sources of new compounds. Sequence data have highlighted numerous gene clusters with unknown products, suggesting an untapped reservoir of such products. Here we discuss the various approaches that have already been used to access these often cryptic metabolites. We consider the likely approaches that might be deployed in the near future to identify and exploit the full metabolic potential of fungi and discuss the possibility of using such enzymes to generate truly novel gene clusters for generating designer metabolites.
Original languageEnglish
Title of host publicationModern Biocatalysis
Subtitle of host publicationAdvances towards synthetic biological systems
EditorsGavin Williams, Melanie Hall
PublisherRoyal Society of Chemistry
Chapter9
Pages234-260
Volume32
Edition1st
ISBN (Electronic)9781788014533
ISBN (Print)9781782627265, 9781788010450
DOIs
Publication statusPublished - 31 May 2018

Publication series

NameCatalysis Series
PublisherRoyal Society of Chemistry
Number32
ISSN (Print)1757-6725
ISSN (Electronic)1757-6733

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