Exploiting Thermoresponsive Polymers to Modulate Lipophilicity: Interactions With Model Membranes

Yussif Saaka, Robert C. Deller, Alison Rodger, Matthew I. Gibson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Abstract

Upon heating above their lower critical solution temperature (LCST) poly[oligo(ethyleneglycol)methacrylate]s (POEGMA) were shown to undergo a shift in their partition coefficient triggering aqueous to organic phase transfer, which indicated their potential to partition into cell membranes upon application of an external stimulus. Fluorescence-based assays indicated that the LCST transition did not induce lysis of model phospholipid vesicles but did promote fusion, as confirmed by dynamic light scattering. Membrane perturbation assays and linear dichroism spectroscopy investigations suggest that POEGMAs above their transition temperatures can interact with, or insert into, membranes. These findings will help develop the application of responsive polymers in drug delivery.

Original languageEnglish
Pages (from-to)779-784
Number of pages6
JournalMacromolecular Rapid Communications
Volume33
Issue number9
DOIs
Publication statusPublished - 14 May 2012

Keywords

  • biological applications of polymers
  • biopolymers
  • membranes
  • reversible addition-fragmentation chain transfer (raft)
  • stimuli-responsive polymers
  • CELL-FUSION
  • NANOPARTICLES
  • GOLD
  • TRANSITION
  • DISCOVERY
  • MICELLES
  • BEHAVIOR
  • DESIGN
  • SIZE

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