Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis

Amy E Taylor, Feng Lu, David J Carslake, Zhibin Hu, Yun Qian, Sijun Liu, Jiaping Chen, Hongbin Chen, George Davey Smith

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)
368 Downloads (Pure)

Abstract

Observational studies suggest that moderate alcohol consumption may be protective for cardiovascular disease, but results may be biased by confounding and reverse causality. Mendelian randomization, which uses genetic variants as proxies for exposures, can minimise these biases and therefore strengthen causal inference. Using a genetic variant in the ALDH2 gene associated with
alcohol consumption, rs671, we performed a Mendelian randomization analysis in 1,712 diabetes cases and 2,076 controls from Nantong, China. Analyses were performed using linear and logistic regression, stratified by sex and diabetes status. The A allele of rs671 was strongly associated with reduced odds of being an alcohol drinker in all groups, but prevalence of alcohol consumption
amongst females was very low. The A allele was associated with reduced systolic and diastolic blood pressure and decreased total and HDL cholesterol in males. The A allele was also associated with decreased triglyceride levels, but only robustly in diabetic males. There was no strong evidence for associations between rs671 and any outcomes in females. Our results suggest that associations of alcohol consumption with blood pressure and HDL-cholesterol are causal. Alcohol also appeared to have adverse effects on triglyceride levels, although this may be restricted to diabetics.
Original languageEnglish
Article number14005
Number of pages6
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 14 Sep 2015

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

Fingerprint Dive into the research topics of 'Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis'. Together they form a unique fingerprint.

Cite this