Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling

Margaritis Voliotis, Kathryn L Garner, Hussah Alobaid, Krasimira Tsaneva-Atanasova, Craig A McArdle

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. FSH and LH control steroidogenesis and gametogenesis in the gonads so GnRH mediates control of reproduction by the central nervous system. GnRH is secreted in short pulses and the effects of GnRH on its target cells are dependent on the dynamics of these pulses. Here we provide a brief overview of the signaling network activated by GnRH with emphasis on the use of high content imaging for their examination. We also describe computational approaches that we have used to simulate GnRH signaling in order to explore dynamics, noise, and information transfer in this system.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages405-429
Number of pages25
Volume1819
DOIs
Publication statusPublished - 2018

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
ISSN (Print)1064-3745

Keywords

  • Computer Simulation
  • Gonadotropin-Releasing Hormone/metabolism
  • HeLa Cells
  • Humans
  • Models, Biological
  • Signal Transduction

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    Voliotis, M., Garner, K. L., Alobaid, H., Tsaneva-Atanasova, K., & McArdle, C. A. (2018). Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling. In Methods in Molecular Biology (Vol. 1819, pp. 405-429). (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-8618-7_19