Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review

Michael Y Jiang; Kerry N L Avery; Rosina Ahmed; Jana de Boniface; Sanjoy Chatterjee; David Dodwell; Peter Dubsky; Sandy Finestone; Hiroji Iwata; Han-Byoel Lee; Mairead McKenzie; Anne Meyn; Fiorita Poulakaki; Andrea Richardson; Karla Sepulveda; Andrew Spillane; Alastair Thompson; Gustavo Werutsky; Jean Wright; Nicholas  Zdenkowski; Katherine Cowan; Stuart A McIntosh; Shelley Potter

doi:10.1016/j.ejso.2024.108554

Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review

Michael Y Jiang, Kerry N L Avery, Rosina Ahmed, Jana de Boniface, Sanjoy Chatterjee, David Dodwell, Peter Dubsky, Sandy Finestone, Hiroji Iwata, Han-Byoel Lee, Mairead McKenzie, Anne Meyn, Fiorita Poulakaki, Andrea Richardson, Karla Sepulveda, Andrew Spillane, Alastair Thompson, Gustavo Werutsky, Jean Wright, Nicholas ZdenkowskiKatherine Cowan, Stuart A McIntosh, Shelley Potter^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Abstract

Accurate information about locoregional treatments in breast cancer neoadjuvant systemic therapy (NST) trials is vital to support surgical decision-making and allow meaningful interpretation of long-term oncological outcomes. This systematic review (PROSPERO registration CRD42023470891) aimed to describe the current practice of outcome reporting in NST studies.

A systematic search identified primary research studies published 01/01/2018-08/09/2023 reporting outcomes in patients receiving NST for breast cancer followed by locoregional treatment. Included were randomised controlled trials (RCTs) and non-randomised studies (NRS) with >250 participants reporting at least one locoregional treatment outcome. Outcomes were extracted verbatim and categorised using content analysis. Descriptive statistics were used to summarise results.

Of the 3,111 abstracts screened, 137 studies (22 RCTs and 115 NRS) reporting at least one locoregional outcome in 575,531 patients were included.

The 137 studies reported a total of 510 surgical outcomes with a median of 3 (range 1-12) per study. No single outcome was reported in all studies. Type of breast (n=129, 94.2%) and axillary (n=86, 62.8%) surgery were reported most frequently. Only 34% (n=47) studies reported how treatment response was assessed and if/how this informed surgical decision-making. Only a fifth (n=28) reported outcomes relating to surgical de-escalation.

Only 72 studies (52.6%) reported any radiation therapy (RT)-related outcome, most frequently whether RT had been received (n=63/72, 87.5%).

Current reporting of locoregional treatment outcomes in NST studies is poor, inconsistent and urgently needs to be improved. A core outcome set and reporting guidelines may improve the quality and value of future research.

Original language	English
Article number	108554
Number of pages	8
Journal	European Journal of Surgical Oncology
Volume	50
Issue number	10
Early online date	22 Jul 2024
DOIs	https://doi.org/10.1016/j.ejso.2024.108554
Publication status	Published - 1 Oct 2024

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© 2024 The Authors

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1 Article (Academic Journal)

Protocol for the development of a core outcome set and reporting guidelines for locoregional treatment in neoadjuvant systemic breast cancer treatment trials: The PRECEDENT Project
Potter, S., Avery, K. N. L., Ahmed, R., De Boniface, J., Chatterjee, S., Dodwell, D., Dubsky, P., Iwata, H., Jiang, M. Y., Lee, H.-B., MacKenzie, M., Poulakaki, F., Richardson, A., Sepulveda, K., Spillane, A., Thompson, A., Werutsky, G., Wright, J., Zendkowski, N. & Cowan, K. & 1 others, McIntosh, S., 19 Apr 2024, In: BMJ Open. 14, 4, 7 p., e084488.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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2 Citations (Scopus)

Cite this

Jiang, M. Y., Avery, K. N. L., Ahmed, R., de Boniface, J., Chatterjee, S., Dodwell, D., Dubsky, P., Finestone, S., Iwata, H., Lee, H.-B., McKenzie, M., Meyn, A., Poulakaki, F., Richardson, A., Sepulveda, K., Spillane, A., Thompson, A., Werutsky, G., Wright, J., ... Potter, S. (2024). Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review. European Journal of Surgical Oncology, 50(10), Article 108554. https://doi.org/10.1016/j.ejso.2024.108554

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title = "Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review",

abstract = "Accurate information about locoregional treatments in breast cancer neoadjuvant systemic therapy (NST) trials is vital to support surgical decision-making and allow meaningful interpretation of long-term oncological outcomes. This systematic review (PROSPERO registration CRD42023470891) aimed to describe the current practice of outcome reporting in NST studies.A systematic search identified primary research studies published 01/01/2018-08/09/2023 reporting outcomes in patients receiving NST for breast cancer followed by locoregional treatment. Included were randomised controlled trials (RCTs) and non-randomised studies (NRS) with >250 participants reporting at least one locoregional treatment outcome. Outcomes were extracted verbatim and categorised using content analysis. Descriptive statistics were used to summarise results. Of the 3,111 abstracts screened, 137 studies (22 RCTs and 115 NRS) reporting at least one locoregional outcome in 575,531 patients were included. The 137 studies reported a total of 510 surgical outcomes with a median of 3 (range 1-12) per study. No single outcome was reported in all studies. Type of breast (n=129, 94.2%) and axillary (n=86, 62.8%) surgery were reported most frequently. Only 34% (n=47) studies reported how treatment response was assessed and if/how this informed surgical decision-making. Only a fifth (n=28) reported outcomes relating to surgical de-escalation. Only 72 studies (52.6%) reported any radiation therapy (RT)-related outcome, most frequently whether RT had been received (n=63/72, 87.5%).Current reporting of locoregional treatment outcomes in NST studies is poor, inconsistent and urgently needs to be improved. A core outcome set and reporting guidelines may improve the quality and value of future research.",

author = "Jiang, {Michael Y} and Avery, {Kerry N L} and Rosina Ahmed and {de Boniface}, Jana and Sanjoy Chatterjee and David Dodwell and Peter Dubsky and Sandy Finestone and Hiroji Iwata and Han-Byoel Lee and Mairead McKenzie and Anne Meyn and Fiorita Poulakaki and Andrea Richardson and Karla Sepulveda and Andrew Spillane and Alastair Thompson and Gustavo Werutsky and Jean Wright and Nicholas Zdenkowski and Katherine Cowan and McIntosh, {Stuart A} and Shelley Potter",

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Jiang, MY, Avery, KNL, Ahmed, R, de Boniface, J, Chatterjee, S, Dodwell, D, Dubsky, P, Finestone, S, Iwata, H, Lee, H-B, McKenzie, M, Meyn, A, Poulakaki, F, Richardson, A, Sepulveda, K, Spillane, A, Thompson, A, Werutsky, G, Wright, J, Zdenkowski, N, Cowan, K, McIntosh, SA & Potter, S 2024, 'Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review', European Journal of Surgical Oncology, vol. 50, no. 10, 108554. https://doi.org/10.1016/j.ejso.2024.108554

TY - JOUR

T1 - Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies

T2 - A systematic review

AU - Jiang, Michael Y

AU - Avery, Kerry N L

AU - Ahmed, Rosina

AU - de Boniface, Jana

AU - Chatterjee, Sanjoy

AU - Dodwell, David

AU - Dubsky, Peter

AU - Finestone, Sandy

AU - Iwata, Hiroji

AU - Lee, Han-Byoel

AU - McKenzie, Mairead

AU - Meyn, Anne

AU - Poulakaki, Fiorita

AU - Richardson, Andrea

AU - Sepulveda, Karla

AU - Spillane, Andrew

AU - Thompson, Alastair

AU - Werutsky, Gustavo

AU - Wright, Jean

AU - Zdenkowski, Nicholas

AU - Cowan, Katherine

AU - McIntosh, Stuart A

AU - Potter, Shelley

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Accurate information about locoregional treatments in breast cancer neoadjuvant systemic therapy (NST) trials is vital to support surgical decision-making and allow meaningful interpretation of long-term oncological outcomes. This systematic review (PROSPERO registration CRD42023470891) aimed to describe the current practice of outcome reporting in NST studies.A systematic search identified primary research studies published 01/01/2018-08/09/2023 reporting outcomes in patients receiving NST for breast cancer followed by locoregional treatment. Included were randomised controlled trials (RCTs) and non-randomised studies (NRS) with >250 participants reporting at least one locoregional treatment outcome. Outcomes were extracted verbatim and categorised using content analysis. Descriptive statistics were used to summarise results. Of the 3,111 abstracts screened, 137 studies (22 RCTs and 115 NRS) reporting at least one locoregional outcome in 575,531 patients were included. The 137 studies reported a total of 510 surgical outcomes with a median of 3 (range 1-12) per study. No single outcome was reported in all studies. Type of breast (n=129, 94.2%) and axillary (n=86, 62.8%) surgery were reported most frequently. Only 34% (n=47) studies reported how treatment response was assessed and if/how this informed surgical decision-making. Only a fifth (n=28) reported outcomes relating to surgical de-escalation. Only 72 studies (52.6%) reported any radiation therapy (RT)-related outcome, most frequently whether RT had been received (n=63/72, 87.5%).Current reporting of locoregional treatment outcomes in NST studies is poor, inconsistent and urgently needs to be improved. A core outcome set and reporting guidelines may improve the quality and value of future research.

AB - Accurate information about locoregional treatments in breast cancer neoadjuvant systemic therapy (NST) trials is vital to support surgical decision-making and allow meaningful interpretation of long-term oncological outcomes. This systematic review (PROSPERO registration CRD42023470891) aimed to describe the current practice of outcome reporting in NST studies.A systematic search identified primary research studies published 01/01/2018-08/09/2023 reporting outcomes in patients receiving NST for breast cancer followed by locoregional treatment. Included were randomised controlled trials (RCTs) and non-randomised studies (NRS) with >250 participants reporting at least one locoregional treatment outcome. Outcomes were extracted verbatim and categorised using content analysis. Descriptive statistics were used to summarise results. Of the 3,111 abstracts screened, 137 studies (22 RCTs and 115 NRS) reporting at least one locoregional outcome in 575,531 patients were included. The 137 studies reported a total of 510 surgical outcomes with a median of 3 (range 1-12) per study. No single outcome was reported in all studies. Type of breast (n=129, 94.2%) and axillary (n=86, 62.8%) surgery were reported most frequently. Only 34% (n=47) studies reported how treatment response was assessed and if/how this informed surgical decision-making. Only a fifth (n=28) reported outcomes relating to surgical de-escalation. Only 72 studies (52.6%) reported any radiation therapy (RT)-related outcome, most frequently whether RT had been received (n=63/72, 87.5%).Current reporting of locoregional treatment outcomes in NST studies is poor, inconsistent and urgently needs to be improved. A core outcome set and reporting guidelines may improve the quality and value of future research.

U2 - 10.1016/j.ejso.2024.108554

DO - 10.1016/j.ejso.2024.108554

M3 - Review article (Academic Journal)

C2 - 39059194

SN - 0748-7983

VL - 50

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 10

M1 - 108554

ER -

Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review

Abstract

Bibliographical note

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Research output

Protocol for the development of a core outcome set and reporting guidelines for locoregional treatment in neoadjuvant systemic breast cancer treatment trials: The PRECEDENT Project

Cite this