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Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalPharmacology and Therapeutics
Volume171
Issue number2017
Early online date2 Dec 2016
DOIs
DateAccepted/In press - 1 Dec 2016
DateE-pub ahead of print - 2 Dec 2016
DatePublished (current) - 1 Mar 2017

Abstract

Ischaemic diseases remain a major cause of morbidity and mortality despite continuous advancements in medical and interventional treatments. Moreover, available drugs reduce symptoms associated with tissue ischaemia, without providing a definitive repair. Cardiovascular regenerative medicine is an expanding field of research that aims to improve the treatment of ischaemic disorders through restorative methods, such as gene therapy, stem cell therapy, and tissue engineering. Stem cell transplantation has salutary effects through direct and indirect actions, the latter being attributable to growth factors and cytokines released by stem cells and influencing the endogenous mechanisms of repair. Autologous stem cell therapies offer less scope for intellectual property coverage and have limited scalability. On the other hand, off-the-shelf cell products and derivatives from the stem cell secretome have a greater potential for large-scale distribution, thus enticing commercial investors and reciprocally producing more significant medical and social benefits. This review focuses on the paracrine properties of cardiac stem cells and pericytes, two stem cell populations that are increasingly attracting the attention of regenerative medicine operators. It is likely that new cardiovascular drugs are introduced in the next future by applying different approaches based on the refinement of the stem cell secretome.

    Research areas

  • Cardiac stem cells, Drug discovery, Pericytes, Regenerative medicine, Secretome

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Pharmacology & Therapeutics at http://www.sciencedirect.com/science/article/pii/S0163725816302339 . Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY

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