Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation

Daniel P. Jones; Tom G. Richardson; George Davey Smith; David Gunnell; Marcus R Munafo; Robyn E Wootton

doi:10.1093/crocol/otaa018

Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation

Daniel P. Jones^*
, Tom G. Richardson
, George Davey Smith
, David Gunnell
, Marcus R Munafo
, Robyn E Wootton

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

13 Citations (Scopus)

150 Downloads (Pure)

Abstract

Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD).

Methods. We used observational techniques followed by Mendelian randomisation (MR) to explore if smoking is a causal factor in the development of IBD and its subtypes.

Results. In those who have ever smoked, we observed increased risk of IBD, and, in current smokers, we observed increased risk of Crohn’s disease and decreased risk of Ulcerative Colitis. However, our MR analyses found little evidence that smoking affects the development of IBD.

Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD.

Original language	English
Number of pages	7
Journal	Crohn's and Colitis 360
Volume	2
Issue number	1
DOIs	https://doi.org/10.1093/crocol/otaa018
Publication status	Published - 12 Mar 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Groups and Themes

Physical and Mental Health
Tobacco and Alcohol
TARG

Keywords

smoking
inflammatory bowel disease
Mendelian randomisation
UK Biobank

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10.1093/crocol/otaa018

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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

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title = "Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation",

abstract = "Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods. We used observational techniques followed by Mendelian randomisation (MR) to explore if smoking is a causal factor in the development of IBD and its subtypes. Results. In those who have ever smoked, we observed increased risk of IBD, and, in current smokers, we observed increased risk of Crohn{\textquoteright}s disease and decreased risk of Ulcerative Colitis. However, our MR analyses found little evidence that smoking affects the development of IBD. Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD.",

keywords = "smoking, inflammatory bowel disease, Mendelian randomisation, UK Biobank",

author = "Jones, \{Daniel P.\} and Richardson, \{Tom G.\} and \{Davey Smith\}, George and David Gunnell and Munafo, \{Marcus R\} and Wootton, \{Robyn E\}",

year = "2020",

month = mar,

day = "12",

doi = "10.1093/crocol/otaa018",

language = "English",

volume = "2",

journal = "Crohn's and Colitis 360",

issn = "2631-827X",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation

AU - Jones, Daniel P.

AU - Richardson, Tom G.

AU - Davey Smith, George

AU - Gunnell, David

AU - Munafo, Marcus R

AU - Wootton, Robyn E

PY - 2020/3/12

Y1 - 2020/3/12

N2 - Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods. We used observational techniques followed by Mendelian randomisation (MR) to explore if smoking is a causal factor in the development of IBD and its subtypes. Results. In those who have ever smoked, we observed increased risk of IBD, and, in current smokers, we observed increased risk of Crohn’s disease and decreased risk of Ulcerative Colitis. However, our MR analyses found little evidence that smoking affects the development of IBD. Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD.

AB - Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods. We used observational techniques followed by Mendelian randomisation (MR) to explore if smoking is a causal factor in the development of IBD and its subtypes. Results. In those who have ever smoked, we observed increased risk of IBD, and, in current smokers, we observed increased risk of Crohn’s disease and decreased risk of Ulcerative Colitis. However, our MR analyses found little evidence that smoking affects the development of IBD. Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD.

KW - smoking

KW - inflammatory bowel disease

KW - Mendelian randomisation

KW - UK Biobank

U2 - 10.1093/crocol/otaa018

DO - 10.1093/crocol/otaa018

M3 - Article (Academic Journal)

C2 - 33506196

SN - 2631-827X

VL - 2

JO - Crohn's and Colitis 360

JF - Crohn's and Colitis 360

IS - 1

ER -

Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation

Abstract

UN SDGs

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Keywords

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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

Cite this